Extra- and intracellular formation of reactive oxygen species by human neutrophils in the presence of pheniramine, chlorpheniramine and brompheniramine.

Author: DrábikováKatarína, HolománováDagmar, JancinováViera, Nosál'Radomír

Paper Details 
Original Abstract of the Article :
Allergic inflammation was found to be accompanied by activation of neutrophils. Since this resulted in increased formation of reactive oxygen species, the antioxidative activity of antiallergic drugs was considered to decrease the risk of tissue damage. However, if the drug-induced inhibition of rad...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/17159800

データ提供:米国国立医学図書館(NLM)

Exploring the Antioxidative Activity of Antiallergic Drugs on Neutrophil Function

The study explores the fascinating world of allergic inflammation and neutrophil function. Allergic inflammation, like a raging desert storm, can wreak havoc on the body. Neutrophils, our immune system's first responders, play a crucial role in combating infection and inflammation. However, their activation can lead to the production of reactive oxygen species (ROS), which can damage tissues. This research investigates the antioxidative activity of antiallergic drugs, specifically pheniramine, chlorpheniramine, and brompheniramine, on both extra- and intracellular ROS production by human neutrophils. The authors highlight the importance of understanding the distinct effects of these drugs on intracellular and extracellular ROS production, as this can influence their overall impact on neutrophil function.

Unveiling the Hidden Secrets of Neutrophil Function

This research is like uncovering hidden oases in the desert of neutrophil function. The study reveals the complex interplay between antiallergic drugs, ROS production, and neutrophil activity. Understanding the intracellular and extracellular effects of these drugs can help us develop more targeted and effective treatments for allergic conditions.

Staying Healthy in the Desert of Allergies

Maintaining a healthy immune system is crucial for navigating the desert of allergies. This research provides valuable insights into the potential impact of antiallergic drugs on immune function. It reminds us of the importance of seeking professional advice and understanding the potential side effects of medications.

Dr.Camel's Conclusion

This study sheds light on the intricate mechanisms involved in allergic inflammation and neutrophil function. Understanding the antioxidative properties of antiallergic drugs can help us develop more effective treatments for allergies. Remember, like a camel traversing a vast desert, we must be well-prepared and equipped to navigate the challenging terrain of allergies.

Date :
  1. Date Completed 2007-06-07
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

17159800

DOI: Digital Object Identifier

NEL270806A32

Related Literature

SNS
PICO Info
in preparation
Languages

English

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