Identifying drugs needing pharmacogenetic monitoring in a Korean hospital.

Author: BaeYoon Young, ChonKung Ju, JeonSu Jin, KangRae Young, KimMin Jung, KimSang Geon, KimYoung Mi, LeeYeon Kyung, ParkKyoung Ho, ShinSang Mi, SonIn Ja, YooSeung Hee

Paper Details 
Original Abstract of the Article :
PURPOSE: A decision matrix for identifying drugs for which pharmacogenetic drug monitoring (PDM) provides the greatest benefit in a Korean setting is described. SUMMARY: We developed a decision matrix including the ethnic frequency of clinically relevant polymorphic cytochrome P-450 (CYP) enzymes, ...See full text at original site
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引用元:
https://doi.org/10.2146/ajhp050490

データ提供:米国国立医学図書館(NLM)

Identifying Drugs Needing Pharmacogenetic Monitoring in a Korean Hospital

In the bustling market of pharmaceuticals, researchers are constantly seeking ways to optimize drug therapy for different populations. This study investigates the potential for pharmacogenetic drug monitoring (PDM) in a Korean hospital setting. PDM is a personalized approach to medication management that considers individual genetic variations to tailor drug therapy. This research is like navigating a marketplace where different medicines may have varying effects on different individuals.

Identifying Drugs for Pharmacogenetic Monitoring

The researchers used a decision matrix based on the frequency of clinically relevant polymorphic cytochrome P-450 (CYP) enzymes in the Korean population to identify drugs for which PDM could provide the greatest benefit. They identified seven drugs, including warfarin, glimepiride, diazepam, amitriptyline, nortriptyline, codeine, and oxycodone, as potential candidates for PDM. This is like identifying the vendors in a marketplace that sell the most sought-after goods. This research highlights the importance of considering genetic variations in drug therapy to ensure optimal treatment outcomes and minimize adverse effects.

Health Benefits and Lifestyle Implications

This research provides valuable insights into the potential benefits of pharmacogenetic drug monitoring in a Korean population. It's like understanding the unique characteristics of a local marketplace and its vendors. This approach to medication management can help to improve treatment outcomes and minimize adverse effects, leading to better overall health and well-being.

Dr. Camel's Conclusion

This research emphasizes the importance of personalized medicine and the role of genetics in tailoring drug therapy. It's like understanding the nuances of a bustling marketplace, where each item has a unique effect on different individuals. By considering genetic variations, healthcare professionals can make more informed decisions about drug therapy, leading to better outcomes for patients.

Date :
  1. Date Completed 2007-04-26
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

17215467

DOI: Digital Object Identifier

10.2146/ajhp050490

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PICO Info
in preparation
Languages

English

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