Paper Details

  1. Home
  2. Paper Details

Antacid interaction with new quinolones: dose regimen recommendations based on pharmacokinetic modeling of clinical data for ciprofloxacin, gatifloxacin and norfloxacin and metal cations.

Author: MiyataK, OhtaniH, SawadaY, TsujimotoM

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study aimed to develop a novel pharmacokinetic model to describe interactions between new quinolones (NQs) and metal cations in order to estimate the optimal dosing interval to minimize drug absorption interference.
Paper Details　
Original Abstract of the Article :
New quinolones (NQs) are widely used to treat various infections. However, concomitant oral administration of metal cations may decrease absorption of NQs and consequently decrease their blood concentration and pharmacological effect. A convenient approach to avoid this interaction is to separate th...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.5414/cpp45063

データ提供：米国国立医学図書館（NLM）

Quinolone Antibiotics and Metal Cations: A Balancing Act in the Desert of Drug Interactions

Quinolone antibiotics are a vital tool in our medical arsenal, like a trusty camel in the desert, helping us combat infections. This study explores the potential interactions between quinolones and metal cations, those mineral ions that can sometimes disrupt the delicate balance of drug absorption and efficacy. The researchers used pharmacokinetic modeling to understand these interactions and develop strategies for optimal dosing.

Minimizing Interactions: Navigating the Desert of Drug Dosages

The study's findings highlight the importance of timing when administering quinolone antibiotics and metal cations. It's like carefully navigating a desert landscape, avoiding treacherous sand dunes and finding the right path to maximize the effectiveness of these medications. By separating dosages by a certain interval, we can minimize interactions and ensure that these essential antibiotics can perform their crucial task of combating infections.

Staying Informed: A Guide to Safe and Effective Medication Use

For those taking quinolone antibiotics, this research emphasizes the importance of consulting with a healthcare professional to understand potential interactions and optimal dosage regimens. By staying informed and working closely with their healthcare team, individuals can confidently navigate the desert of medications and ensure their safe and effective use.

Dr.Camel's Conclusion

This study emphasizes the crucial role of pharmacokinetic modeling in understanding drug interactions. By applying this knowledge, we can optimize the use of essential medications like quinolone antibiotics, ensuring their effectiveness and minimizing potential risks. It's a testament to the power of scientific research to illuminate the complexities of our desert of drug interactions and guide us towards safer and more effective treatment options.

Date :
  1. Date Completed 2007-03-02
  2. Date Revised 2019-06-08
Further Info :

Pubmed ID

17256452

DOI: Digital Object Identifier

10.5414/cpp45063

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.