Lack of indinavir-associated nephrological complications in HIV-infected adults (predominantly women) with high indinavir plasma concentration in Abidjan, Côte d'Ivoire.

Author: AnglaretXavier, AnzianAmani, BissagneneEmmanuel, DanelChristine, GabillardDelphine, GomisOlivier Ba, MingaAlbert, MohRaoul, NzunettuGustave, PeytavinGilles, SalamonRoger, SeriBoga

Paper Details 
Original Abstract of the Article :
To report the tolerance of indinavir combined with ritonavir (IDV/r 800/100 mg) twice daily (bid) in sub-Saharan African HIV-infected adults. HAART-naives patients started zidovudine plus lamivudine plus IDV/r 800/100 mg bid. Follow-up included standardized documentation of morbidity, CD4(+) cell co...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/17263634

データ提供:米国国立医学図書館(NLM)

Indinavir's Impact on HIV-Infected Adults in Abidjan

The realm of HIV/AIDS research is an arid desert of challenges, where scientists constantly search for oases of effective treatment. This study investigates the efficacy and tolerability of indinavir, a potent antiretroviral drug, in a group of HIV-infected adults in Abidjan, Côte d'Ivoire. The researchers employed a prospective observational design to assess the impact of indinavir, combined with ritonavir, on the patients' health outcomes. The study revealed that indinavir led to significant reductions in viral load and improvements in CD4 cell counts, a positive sign in the fight against HIV infection. However, the study also observed a high incidence of digestive intolerance, highlighting the importance of individualized therapy for managing side effects.

The Mystery of Indinavir Tolerance in Sub-Saharan Africa

The study revealed a surprising lack of nephrological side effects, which is particularly interesting. This suggests that indinavir might be better tolerated by individuals in sub-Saharan Africa than in Americans or Europeans. This intriguing observation deserves further exploration, as it could potentially inform future HIV treatment strategies.

Navigating the Desert of HIV Treatment

This research underscores the importance of tailored treatment approaches, considering the unique characteristics of different patient populations. The study's findings serve as a valuable reminder that while we strive to conquer the vast desert of HIV infection, we must be prepared for the unexpected and navigate with caution, always seeking the most effective path for each individual.

Dr.Camel's Conclusion

This study sheds light on the complex landscape of HIV treatment. While indinavir offers hope for many, we must remember that each patient is unique. We must approach treatment with care, recognizing the importance of individualized therapy and understanding the nuances of drug response in diverse populations. It is important to embrace the desert of unknowns and continue our journey towards finding even more effective and tolerable therapies for all individuals.

Date :
  1. Date Completed 2007-04-11
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

17263634

DOI: Digital Object Identifier

HALMS173523

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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