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Quetiapine augmentation of treatment-resistant depression: a comparison with lithium.

Author: Des RosiersJoël, DoréeJean-Pierre, ElieRobert, GendronAlain, LewViviane, StipEmmanuel, TourjmanS Valérie

Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This open-label, comparative study compared quetiapine with lithium in the augmentation of treatment-resistant depression. The study found that quetiapine was an effective augmenting agent in treatment-resistant depression.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: The prevalence of and morbidity associated with treatment-resistant depression has motivated the exploration of treatment alternatives. In this study, quetiapine was compared with lithium in the augmentation of treatment-resistant depression. RESEARCH DESIGN AND METHODS: Open-label, comp...See full text at original site
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引用元：
https://doi.org/10.1185/030079906X162809

データ提供：米国国立医学図書館（NLM）

Quetiapine: A New Oasis in the Desert of Treatment-Resistant Depression

Treatment-resistant depression (TRD) can be a formidable challenge, with many patients struggling to find effective therapies. This research explores the efficacy of quetiapine as an augmentation agent in TRD, comparing its effectiveness to lithium. The study aims to provide a comparative analysis of quetiapine and lithium in augmenting existing antidepressant treatments in patients with TRD.

Quetiapine: A Potential Game-Changer for TRD

The study, conducted on 20 patients with TRD, demonstrated a significant improvement in depression symptoms in both quetiapine and lithium groups. However, quetiapine showed a greater improvement in depression severity compared to lithium, particularly in the later stages of treatment. These findings suggest that quetiapine may be a more effective augmentation agent for TRD.

Finding Hope in the Desert of TRD

This research offers a glimmer of hope for individuals struggling with TRD. The study's findings suggest that quetiapine could provide a more effective treatment option for this challenging condition. However, remember, treatment for TRD is highly individualized. It's crucial to work closely with a healthcare professional to determine the most effective treatment for your specific needs.

Dr. Camel's Conclusion

This research is like a camel caravan exploring a new oasis in the vast desert of TRD. Quetiapine shows promise as a potential solution, offering a more effective path to healing. However, as with any oasis, further exploration and careful navigation are needed to maximize its benefits.

Date :
  1. Date Completed 2007-03-15
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

17288688

DOI: Digital Object Identifier

10.1185/030079906X162809

Related Literature

Article Analysis
・Effective treatment of depression
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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