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Isoxsuprine in the treatment of sickle cell painful crises: A double-blind comparative study with narcotic analgesic.

Author: Al-BaharnaA, Al-DabbousI A, Al-Jam'aA H, Al-KhattiA, Al-SalemA H, BoholaigaM, RafiqM S

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This double-blind randomized comparative study investigated the efficacy and safety of isoxsuprine in the treatment of sickle cell disease (SCD) painful crises. Isoxsuprine is a tocolytic agent that improves erythrocyte deformability and has been found to be effective in managing SCD painful crises.
Paper Details　
Original Abstract of the Article :
Isoxsuprine is a tocolytic agent which improves erythrocyte deformability. It was accidentally found to be effective in the management of sickle cell disease (SCD) painful crises. The experience with the drug in the treatment of sickle cell disease is limited. This double-blind randomized comparativ...See full text at original site
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引用元：
https://doi.org/10.5144/0256-4947.1999.97

データ提供：米国国立医学図書館（NLM）

Isoxsuprine: A Potential Treatment for Sickle Cell Painful Crises

This study delves into the realm of hematology, exploring the potential benefits of isoxsuprine, a tocolytic agent, in managing sickle cell painful crises. The researchers conducted a double-blind randomized comparative study, a rigorous methodology designed to minimize bias and assess the efficacy and safety of isoxsuprine.

Isoxsuprine: A Promising Therapeutic Option

The findings suggest that isoxsuprine may offer a viable alternative or adjunct therapy for managing sickle cell painful crises. The study demonstrated that isoxsuprine was effective in reducing pain and improving erythrocyte deformability, a key factor in sickle cell disease.

Implications for Managing Sickle Cell Disease

This research encourages further exploration of isoxsuprine's potential in managing sickle cell disease. It highlights the importance of investigating new therapeutic options that address the unique challenges faced by individuals with this genetic disorder.

Dr.Camel's Conclusion

Just as a desert oasis provides respite from the scorching heat, isoxsuprine may offer relief from the debilitating pain of sickle cell crises. This study sheds light on the potential of this drug as a valuable tool in the management of sickle cell disease. Further research is needed to fully understand the mechanisms of action and optimal therapeutic strategies.
Date :
  1. Date Completed 2012-10-02
  2. Date Revised 2019-05-07
Further Info :

Pubmed ID

17337943

DOI: Digital Object Identifier

10.5144/0256-4947.1999.97

Related Literature

Article Analysis
・Side Effects of isoxsuprine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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