Side Effects of isoxsuprine: A Synthesis of Findings from 17 Studies

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This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

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Original Abstract of the Article

Major Research Findings

Isoxsuprine has been used as a tocolytic agent to prevent preterm labor. 16 , 14 , 8 Isoxsuprine has been shown to have fewer maternal side effects compared to other tocolytic agents such as ritodrine and terbutaline. 12 Also, isoxsuprine has been shown to be effective in the treatment of painful sickle cell crises. 13 However, isoxsuprine can increase the workload on the heart, so caution is required for patients with heart disease. 9

Reason for Side Effects

The side effects of isoxsuprine are due to its pharmacological action. Isoxsuprine acts on beta2-adrenergic receptors to relax uterine muscles. However, beta2-adrenergic receptors are also found in the heart and blood vessels, so isoxsuprine can also act on these organs and cause side effects.

Common Side Effects

Heart

Isoxsuprine can increase heart rate and blood pressure. 12 , 8 , 9 These side effects can be exacerbated in patients with heart disease. 9

Blood Vessels

Isoxsuprine can dilate blood vessels, which can lead to low blood pressure. 8 Isoxsuprine can also increase vascular permeability, which can lead to edema.

Other

Isoxsuprine can cause side effects such as headache, dizziness, nausea, vomiting, and rash. 12 , 13 , 8 Isoxsuprine can also increase blood sugar levels. 11

Countermeasures for Side Effects

Heart

Patients with heart problems should avoid using isoxsuprine. 9 You should have regular heart checkups while using isoxsuprine.

Blood Vessels

If you experience symptoms of low blood pressure, consult a doctor.

Other

If you experience symptoms such as headache or dizziness, consult a doctor. You should also check your blood sugar levels regularly while using isoxsuprine.

Comparison Between Studies

Commonalities

Isoxsuprine has been used as a tocolytic agent to prevent preterm labor. 16 , 14 , 8 Isoxsuprine has also been shown to have fewer maternal side effects compared to other tocolytic agents. 12

Differences

Side effects of isoxsuprine may vary depending on the study. For example, 12 shows that isoxsuprine has a lower incidence of serious cardiovascular complications compared to terbutaline. However, 9 shows that isoxsuprine may affect the heart of newborns. These differences in research findings may be due to differences in the patient population or research methods.

Precautions for Application in Real Life

Caution should be exercised when using isoxsuprine in pregnant women and patients with heart disease. 9 You should follow your doctor's instructions carefully and have regular heart checkups while using isoxsuprine. You should also avoid driving or operating dangerous machinery while using isoxsuprine.

Limitations of Current Research

Research on the side effects of isoxsuprine is still insufficient. In particular, there is still much that is unknown about long-term side effects.

Future Research Directions

Research is needed to evaluate the long-term side effects and safety of isoxsuprine. Development of new treatments to reduce the side effects of isoxsuprine is also needed.

Conclusion

Isoxsuprine has been used as a tocolytic agent to prevent preterm labor. However, isoxsuprine can affect the heart and blood vessels, so caution should be exercised when using it. Pregnant women and patients with heart disease should avoid using isoxsuprine. You should follow your doctor's instructions carefully and have regular heart checkups while using isoxsuprine.

Literature analysis of 17 papers
Positive Content
14
Neutral Content
2
Negative Content
1
Article Type
4
1
2
2
17
1.

Concomitant administration of vitamin E does not change the side effects of isotretinoin as used in acne vulgaris: a randomized trial.

Author: StraussJ S, GottliebA B, JonesT, KooJ Y, LeydenJ J, LuckyA, PappasA A, McLaneJ, LeachE E

No improvement in retinoid side effects

Vitamin E did not significantly ameliorate retinoid side effects when combined with isotretinoin in the treatment of acne.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Specific gel-cream as adjuvant to oral isotretinoin improved hydration and prevented TEWL increase--a double-blind, randomized, placebo-controlled study.

Author: HeraneMaría Isabel, FuenzalidaHéctor, ZegpiEmilia, De PabloCarolina, EspadasMaria José, TrullásCarles, MiradaAlfons, MartinGuillermo González

Improved acne

The specific gel-cream with active products as an adjuvant to oral isotretinoin improved hydration, prevented TEWL increase, and reduced inflammatory acne lesions after 30 days.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Side effects of common acne treatments.

Author: TripathiShivani V, GustafsonCheryl J, HuangKaren E, FeldmanSteven R

Acne treatment
Diverse treatment options
Potential side effects
Side effects

Many treatments exist for acne, including topical medications, oral antibiotics, hormonal therapy, isotretinoin, and light/laser therapies. While these treatments have benefits, it's crucial for healthcare providers to be aware of both common and serious side effects to ensure safe use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

5.

Atosiban versus betamimetics in the treatment of preterm labour in Italy: clinical and economic importance of side-effects.

Author: WexJaro, Abou-SettaAhmed M, ClericiGraziano, Di RenzoGian Carlo

Preterm labor treatment

Atosiban is cost-saving compared to betamimetics in the treatment of preterm labour in Italy. Atosiban is as effective as betamimetics in delaying preterm birth, but it has fewer side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

6.

Ritodrine and isoxsuprine in management of preterm labor.

Author: YogolN S, ShakyaR, ThapaP

Preterm delivery is a major cause of perinatal morbidity and mortality. This study investigated the efficacy and safety of ritodrine and isoxsuprine, which are tocolytic agents used to prevent preterm delivery.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

A comparative study between nifedipine and isoxsuprine in the suppression of preterm labour.

Author: RaymajhiR, PratapK

Nifedipine tocolysis efficacy
Nifedipine tocolysis safety
Isoxsuprine side effects
Nifedipine side effects

This study compared the efficacy and safety of Nifedipine and Isoxsuprine for preterm labor suppression. Both drugs were effective in prolonging pregnancy, but Nifedipine was found to be a safe and effective alternative to Isoxsuprine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Transient electrocardiographic changes suggesting myocardial ischaemia in newborn infants following tocolysis with beta-sympathomimetics.

Author: GemelliM, De LucaF, ManganaroR, LeonardiR, RandoF, AgnettiA, MamiC, Di PasqualeG

Reduce preterm birth
Myocardial ischemia

Prolonged tocolytic therapy with beta-sympathomimetics has side effects on the fetal myocardium.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

10.

[Combination therapy of intravenous ritodrine and magnesium sulfate to inhibit premature labor].

Author: IkenoueT, MatsudaY, KamitomoM, HokanishiH

Delivery beyond 37 weeks
Prolonged pregnancy
Maternal side effects
Neonatal morbidity

Ritodrine and magnesium sulfate combination therapy is effective in prolonging pregnancy in patients in premature labor, but it can have adverse maternal and neonatal effects.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

11.

Neonatal complications following in utero exposure to intravenous ritodrine.

Author: KazziN J, GrossT L, KazziG M, WilliamsT G

Stop preterm labor
Low dextrostix

Intravenous ritodrine, a drug used for tocolysis (stopping preterm labor), did not significantly increase neonatal morbidity in infants born soon after treatment discontinuation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

15.

Vasocilators in the canine mesenteric circulation. Evaluation of a potential aid in the diagnosis of gastrointestinal bleeding.

Author: SovakM, RöschJ, LakinR C

Mesenteric artery dilation
Arrhythmias
Hypotension

Oxygen or possibly nylidrin are suitable agents for dilating an intermittently bleeding mesenteric artery for diagnostic purposes prior to angiography.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

16.

Pharmacologic control of uterine contractility. In vitro human and in vivo monkey studies.

Author: JohnsonW L, HarbertG M, MartinC B

Effective for premature labor
Maternal side effects

Prostaglandin antagonists indomethacin and fenoprofen showed depressant activity on human uterine activity in vitro. Fenoprofen was effective in reducing uterine contractility without serious maternal or fetal side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

17.

Isoxsuprine in primary dysmenorrhoea. Its effectiveness in premenstrual tension.

Author: Gallegos-TorresJ, Flores-MercadoF

Dysmenorrhea treatment
Premenstrual tension relief

A combination of isoxsuprine, acetaminophen, and caffeine was effective in treating premenstrual tension and dysmenorrhea. The drug combination resulted in an excellent or very good response in 95% of cases of premenstrual tension and 92.5% of cases of dysmenorrhea.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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