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Chlorpromazine versus placebo for schizophrenia.

Author: AdamsC E, AwadG, RathboneJ, ThornleyB

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Chlorpromazine reduces relapse over the short and medium term, and provides a global improvement in symptoms and functioning. It is also associated with adverse effects such as sedation, acute movement disorders, parkinsonism, lowered blood pressure, and weight gain.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Chlorpromazine, formulated in the 1950s, remains a benchmark treatment for people with schizophrenia. OBJECTIVES: To evaluate the effects of chlorpromazine for schizophrenia in comparison with placebo. SEARCH STRATEGY: We updated previous searches of the Cochrane Schizophrenia Group Re...See full text at original site
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引用元：
https://doi.org/10.1002/14651858.CD000284.pub2

データ提供：米国国立医学図書館（NLM）

Chlorpromazine for Schizophrenia: A Review of Clinical Trials

This research delves into the realm of mental health treatment, evaluating the efficacy of chlorpromazine, a long-standing antipsychotic medication, in treating schizophrenia. The study aimed to systematically review randomized controlled trials (RCTs) comparing chlorpromazine with placebo in patients with schizophrenia. The authors sought to provide a comprehensive overview of the evidence supporting chlorpromazine's use as a treatment for this debilitating mental disorder.

Chlorpromazine's Effectiveness in Schizophrenia Treatment

The review found that chlorpromazine reduces the risk of relapse in schizophrenia over both short and medium-term follow-ups. It also demonstrated a global improvement in patients' symptoms and functioning, with fewer people leaving the trials early in the chlorpromazine group compared to the placebo group. However, the review also highlighted significant adverse effects associated with chlorpromazine, including sedation, movement disorders, and weight gain.

Navigating Antipsychotic Treatment

This study, like a journey through the vast desert of mental health treatment options, provides a balanced perspective on the use of chlorpromazine for schizophrenia. While it shows effectiveness in reducing relapse and improving symptoms, it also underscores the importance of carefully considering the potential adverse effects.

Dr.Camel's Conclusion

This research, like a camel caravan crossing a desert of mental health challenges, offers insights into the use of chlorpromazine, a long-established treatment for schizophrenia. While chlorpromazine remains a valuable option, the study highlights the need for careful monitoring and consideration of potential side effects.
Date :
  1. Date Completed 2007-07-17
  2. Date Revised 2020-05-11
Further Info :

Pubmed ID

17443500

DOI: Digital Object Identifier

10.1002/14651858.CD000284.pub2

Related Literature

Article Analysis
・Effective treatment of schizophrenia
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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