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Targeted nalmefene with simple medical management in the treatment of heavy drinkers: a randomized double-blind placebo-controlled multicenter study.

Author: KallioAntero, KarhuvaaraSakari, LöyttyniemiEliisa, MäkeläRauno, NurminenTommi, RosbergMarkus, SimojokiKaarlo, VirtaAntti

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Nalmefene, an opioid antagonist, was found to be effective and safe in reducing heavy drinking, even when minimal psychosocial support was provided. This multisite, randomized, double-blind study involving 403 patients with problem drinking found that nalmefene significantly reduced the number of heavy drinking days compared to placebo.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Clinical studies with opioid antagonists for treatment of problem drinking have mainly been conducted in specialized alcohol treatment centers, included structured psychosocial treatment, and have focused on maintaining abstinence after a period of abstinence from alcohol. METHODS: This...See full text at original site
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引用元：
https://doi.org/10.1111/j.1530-0277.2007.00401.x

データ提供：米国国立医学図書館（NLM）

Targeted Nalmefene for Heavy Drinkers: An Oasis of Hope in the Desert of Alcohol Dependence

The field of alcohol dependence research is always seeking effective and safe treatments to help individuals overcome their struggles. This study investigated the potential of nalmefene, an opioid antagonist, as a targeted treatment for heavy drinking. The researchers conducted a randomized, double-blind, placebo-controlled trial, which is a rigorous study design like a camel caravan setting out on a long and difficult journey across a vast desert. The goal was to assess whether nalmefene could reduce heavy drinking episodes when taken on demand, meaning that patients could take the medication when they felt the urge to drink heavily.

Nalmefene and Heavy Drinking: A Promising Result in the Desert

The study found that nalmefene was effective in reducing heavy drinking days compared to a placebo. This encouraging result is like finding a refreshing oasis in the desert. The authors concluded that nalmefene appears to be a safe and effective treatment option for reducing heavy drinking, even when accompanied by minimal psychosocial support.

Navigating the Desert of Alcohol Dependence: Seeking Support and Finding Balance

This study highlights the importance of exploring different treatment options for alcohol dependence. Individuals struggling with alcohol dependence should seek help from healthcare professionals and support groups. It's like seeking guidance and support from fellow travelers in a desert. They should also consider the potential benefits of nalmefene as a targeted treatment option, particularly when combined with appropriate psychosocial support.

Dr.Camel's Conclusion

The desert of alcohol dependence is a harsh and unforgiving place. This research offers a beacon of hope for those seeking help. Nalmefene, as a targeted treatment option, holds promise for reducing heavy drinking and improving the lives of individuals struggling with alcohol dependence. As a wise camel, I encourage everyone to seek support and guidance on their journey through this challenging desert.

Date :
  1. Date Completed 2007-07-24
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

17451401

DOI: Digital Object Identifier

10.1111/j.1530-0277.2007.00401.x

Related Literature

Article Analysis
・Effective treatment of alcohol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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