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Phenoxodiol-Topotecan co-administration exhibit significant anti-tumor activity without major adverse side effects.

Author: AlveroAyesha B, BrownDavid, MatthewsMarissa, MontagnaMichele, MorGil

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Phenoxodiol-Topotecan combination therapy was found to be more effective than monotherapy in treating epithelial ovarian cancer. This study, involving nine ovarian cancer cell lines and an animal model, found that co-administration of phenoxodiol and topotecan resulted in significant anti-tumor activity and reversed topotecan-induced myelosuppression.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: We previously showed that Phenoxodiol is able to sensitize epithelial ovarian cancer cells to Paclitaxel, Carboplatin, Gemcitabine, and Docetaxel. The aim of this study was to determine the value of Phenoxodiol-Topotecan coadministration. METHODS: Nine epithelial ovarian cancer cell line...See full text at original site
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引用元：
https://doi.org/10.4161/cbt.6.4.3891

データ提供：米国国立医学図書館（NLM）

Phenoxodiol-Topotecan Combination Therapy for Ovarian Cancer: A Promising Approach

The fight against cancer is like navigating a treacherous desert, full of obstacles and challenges. This study investigates a potential new treatment strategy for ovarian cancer, combining two drugs: phenoxodiol and topotecan. The researchers found that this combination therapy was significantly more effective than either drug alone, showing promise for improving treatment outcomes.

Phenoxodiol Enhances the Effectiveness of Topotecan

The study demonstrated that phenoxodiol, when combined with topotecan, significantly increased the drug's effectiveness in killing ovarian cancer cells. This synergistic effect could lead to better tumor control and potentially improved survival rates for patients.

A New Weapon in the Fight Against Ovarian Cancer

This research offers a ray of hope for patients with ovarian cancer. The phenoxodiol-topotecan combination therapy holds the potential to provide a more effective and less toxic treatment option. Further research is needed to confirm these findings in clinical trials, but this promising approach could significantly impact the fight against this challenging disease.

Dr. Camel's Conclusion

This research is a beacon of hope in the ongoing battle against ovarian cancer. The synergistic effect of phenoxodiol and topotecan offers a potential new weapon in our arsenal. Just as a camel can navigate the desert with its unique adaptations, researchers continue to seek innovative approaches to overcome the challenges of cancer treatment.

Date :
  1. Date Completed 2007-12-17
  2. Date Revised 2020-09-30
Further Info :

Pubmed ID

17457041

DOI: Digital Object Identifier

10.4161/cbt.6.4.3891

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Article Analysis
・Effects of topotecan・Side Effects of topotecan
SNS
PICO Info
in preparation
Languages

English

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