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Controlled trials in pediatric migraine: crossover versus parallel group.

Author: EversStefan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Research on migraine treatments for children and teens is limited and challenging to design. Studies where everyone receives both a real treatment and a placebo (crossover trials) show a lower placebo effect and greater effectiveness of treatments compared to studies where participants only receive one treatment (parallel group trials). Future research on migraine treatments for children should consider using crossover designs.
Paper Details　
Original Abstract of the Article :
Studies on the treatment of migraine in children and adolescents are rare and difficult to design. In particular, the high placebo response makes it difficult to show efficacy of a verum drug. When analyzing all published trials in the acute drug treatment of migraine in children, crossover trials s...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.1007/s11916-007-0197-1

データ提供：米国国立医学図書館（NLM）

Pediatric Migraine: Navigating the Placebo Maze

This study explores the challenges of conducting controlled trials for pediatric migraine, a condition that can cause significant discomfort and disrupt daily life for young patients. The study examines the high placebo response in pediatric migraine, making it difficult to reliably assess the efficacy of verum drugs. The researchers delved into the literature, analyzing published trials on acute drug treatment for pediatric migraine, and compared the effectiveness of crossover trials to parallel group trials.

Crossover Trials: A Superior Approach for Pediatric Migraine

The analysis revealed that crossover trials, which allow patients to receive both placebo and verum treatments, exhibit lower placebo rates and higher therapeutic gain compared to parallel group trials. This finding has significant implications for future research designs, suggesting that crossover trials may be a more effective approach for evaluating acute drug treatments in pediatric migraine.

Migraine in Children: A Challenging Journey

This study highlights the challenges of managing migraine in children, emphasizing the need for careful consideration of research designs to minimize the impact of placebo effects. The study also underscores the importance of finding effective treatments for pediatric migraine, a condition that can have a significant impact on quality of life.

Dr. Camel's Conclusion

This research emphasizes the importance of utilizing crossover trials for evaluating acute drug treatments in pediatric migraine, due to the high placebo response in this population. This approach offers a promising avenue for more accurate and reliable assessment of treatment efficacy, paving the way for better management of migraine in children.
Date :
  1. Date Completed 2007-07-03
  2. Date Revised 2022-07-16
Further Info :

Pubmed ID

17504653

DOI: Digital Object Identifier

10.1007/s11916-007-0197-1

Related Literature

Article Analysis
・Effective treatment of migraine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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