Combined therapeutic effects of vinblastine and rapamycin on human neuroblastoma growth, apoptosis, and angiogenesis.

Author: BrignoleChiara, CilliMichele, Di PaoloDaniela, LongoLuca, MarimpietriDanilo, NicoBeatrice, PagnanGabriella, PastorinoFabio, PerriPatrizia, PezzoloAnnalisa, PiccardiFederica, PonzoniMirco, RibattiDomenico

Paper Details 
Original Abstract of the Article :
PURPOSE: Vinblastine and rapamycin displayed synergistic inhibition of human neuroblastoma-related angiogenesis. Here, we studied the antitumor activity of vinblastine and rapamycin against human neuroblastoma. EXPERIMENTAL DESIGN: Cell proliferation, cell cycle progression, and apoptosis were eval...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1158/1078-0432.CCR-06-2757

データ提供:米国国立医学図書館(NLM)

Vinblastine and Rapamycin: A Synergistic Approach to Combating Neuroblastoma

Neuroblastoma, a type of childhood cancer, can be a formidable opponent. This study investigates the potential of combining two drugs, vinblastine and rapamycin, to combat this aggressive disease. The authors conducted a series of experiments to assess the effects of these drugs on human neuroblastoma cells in both laboratory settings and in mice with neuroblastoma. Their research showed that when used together, vinblastine and rapamycin had a synergistic effect, inhibiting cell growth, inducing apoptosis (programmed cell death), and suppressing angiogenesis (the formation of new blood vessels). The study provides promising evidence that this drug combination could be a valuable therapeutic strategy for treating neuroblastoma.

Combating Neuroblastoma: A Two-Pronged Attack

This research explores a novel approach to battling neuroblastoma, a challenging cancer that often affects young children. The authors, like astute strategists, developed a two-pronged attack, combining vinblastine and rapamycin to effectively target neuroblastoma cells. Their findings, like a well-placed arrow striking its target, offer hope for more effective treatment options for neuroblastoma patients.

A Camel's Advice: Early Detection and Comprehensive Care for Neuroblastoma

Neuroblastoma is a complex and aggressive disease, and early detection is crucial for improving treatment outcomes. If you have concerns about your child's health, don't hesitate to consult with a medical professional. A comprehensive approach to treatment, involving a multidisciplinary team of specialists, can provide the best chance for successful outcomes. The journey to fighting neuroblastoma requires a united front, with both medical experts and families working together to overcome this challenge.

Dr.Camel's Conclusion

This study demonstrates the promise of combining vinblastine and rapamycin to combat neuroblastoma. The researchers' innovative approach, like a caravan navigating a challenging terrain, opens new avenues for treating this difficult disease, offering hope for improved outcomes for children battling this devastating cancer.

Date :
  1. Date Completed 2007-09-06
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

17606732

DOI: Digital Object Identifier

10.1158/1078-0432.CCR-06-2757

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.