Transitioning patients from cangrelor to clopidogrel: pharmacodynamic evidence of a competitive effect.

Author: AkersWendell S, CharnigoRichard, FerrarisSuellen, OestreichJulie H, OhJennifer J, SteinhublSteven R

Paper Details 
Original Abstract of the Article :
Cangrelor is a direct, parenteral, and reversible inhibitor of the platelet P2Y12 receptor currently undergoing Phase III testing. As many individuals treated acutely with cangrelor will often be treated long-term with a thienopyridine, it is important to determine the effects of concurrent cangrelo...See full text at original site
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引用元:
https://doi.org/10.1016/j.thromres.2007.05.020

データ提供:米国国立医学図書館(NLM)

Transitioning Patients from Cangrelor to Clopidogrel

Cardiovascular research is a field filled with intricate pathways and complex mechanisms. This research explores the delicate dance of transitioning patients from cangrelor, a direct inhibitor of the platelet P2Y12 receptor, to clopidogrel, a thienopyridine. The researchers used pharmacodynamic evidence to unravel the intricate relationship between these two drugs, specifically looking for a competitive effect. Imagine a bustling marketplace, where cangrelor and clopidogrel are vying for the same customers - those pesky platelets. This study aimed to understand how these two medications compete for their target, shedding light on potential interactions and optimizing patient care.

Cangrelor and Clopidogrel: A Tale of Two Medications

The study revealed evidence of a competitive effect between cangrelor and clopidogrel. This means that the two medications are in a constant tug-of-war for the same receptor, which can potentially impact treatment outcomes. Think of it like a race between two camels across the vast desert. Cangrelor and clopidogrel are like our camels, both aiming to reach the same destination, but sometimes their paths cross, leading to a competition. This study provides crucial information for clinicians to understand how to effectively manage transitions between these two medications, ensuring optimal patient outcomes.

Understanding the Implications for Patient Care

The researchers highlight the importance of careful consideration when transitioning patients from cangrelor to clopidogrel. They emphasize that understanding the interplay between these two medications is essential for tailoring treatment strategies. Just as a wise traveler in the desert must choose the right path for their journey, clinicians must carefully navigate the transition from cangrelor to clopidogrel, ensuring patient safety and efficacy.

Dr.Camel's Conclusion

This research emphasizes the importance of understanding drug interactions in cardiovascular medicine. It provides valuable insights into the dynamic relationship between cangrelor and clopidogrel, which can guide clinicians in optimizing patient care. By unraveling the intricate interplay between these two medications, we can improve patient safety and achieve optimal outcomes in the vast desert of cardiovascular health.

Date :
  1. Date Completed 2008-04-08
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

17631948

DOI: Digital Object Identifier

10.1016/j.thromres.2007.05.020

Related Literature

SNS
PICO Info
in preparation
Languages

English

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