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Use of losartan in reducing microalbuminuria in normotensive patients with type-2 diabetes mellitus.

Author: AghaAdnan, AnwarEram, BashirKaukab

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study found that losartan, an angiotensin receptor blocker (ARB), significantly reduced microalbuminuria in normotensive patients with type-2 diabetes mellitus (T2DM). These effects were reversible after discontinuation of treatment. The study suggests that losartan could be a preventive therapy for diabetic nephropathy, but further research is needed.
Paper Details　
Original Abstract of the Article :
Type-2 diabetes mellitus (T2DM) is a global disease and its resultant complication, diabetic nephropathy, is a leading cause of chronic renal failure. Microalbuminuria is an early indicator of diabetic nephropathy and is also an independent risk factor for cardiovascular morbidity. Data have shown t...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/17899953

データ提供：米国国立医学図書館（NLM）

Losartan in Reducing Microalbuminuria in Normotensive Type-2 Diabetes Patients

This study investigates the potential of losartan, an angiotensin receptor blocker (ARB), in reducing microalbuminuria, an early marker of diabetic nephropathy, in normotensive patients with type-2 diabetes mellitus (T2DM). The study explores the anti-microalbuminuric effects of losartan independent of its blood pressure-lowering properties.

Losartan's Anti-Microalbuminuric Effects

The study demonstrates the significant anti-microalbuminuric effects of losartan therapy in normotensive T2DM patients. The findings suggest that losartan can effectively reduce albuminuria, even in the absence of hypertension. This is like finding a hidden spring in a desert oasis, providing a source of relief and protection from the harsh environment.

Clinical Implications for Diabetic Nephropathy

The study's findings have significant implications for the management of diabetic nephropathy. Losartan's anti-microalbuminuric properties suggest that it could play a crucial role in preventing the progression of renal disease in T2DM patients, even in the absence of hypertension. This is like creating a protective barrier around a fragile desert ecosystem, shielding it from the destructive forces of the environment.

Dr. Camel's Conclusion

The study presents a compelling case for the use of losartan in managing diabetic nephropathy, demonstrating its effectiveness in reducing microalbuminuria. This finding provides a valuable tool in the fight against this debilitating condition, like discovering a hidden oasis in the desert, offering a source of hope and healing for individuals with T2DM.

Date :
  1. Date Completed 2007-11-08
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

17899953

DOI: Digital Object Identifier

17899953

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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