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Avoidance behaviour: a predictor of the efficacy of pharmacotherapy in panic disorder?

Author: ArgyleN, BenkertO, BrandonS, BullerR, LavoriP, MaierW, RothS M

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study of 1134 patients with panic disorder compared the effectiveness of alprazolam, imipramine, and placebo in treating panic disorder, specifically examining the impact of avoidance behavior (agoraphobia). The study found that patients with agoraphobia had the greatest benefit from active medications, particularly imipramine. This suggests that agoraphobia may be a distinct type of anxiety disorder rather than just a severe form of panic disorder, and that imipramine may be a more effective treatment option for patients with agoraphobic symptoms.
Paper Details　
Original Abstract of the Article :
The impact of the avoidance behaviour on the psychopharmacological treatment of panic disorder was explored in the Cross National Collaborative Panic Study (n = 1134 patients); in this double blind randomized trial alprazolam, imipramine and placebo were compared during an 8-week treatment period. P...See full text at original site
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引用元：
https://doi.org/10.1007/BF02219714

データ提供：米国国立医学図書館（NLM）

Avoidance Behaviour: A Predictor of the Efficacy of Pharmacotherapy in Panic Disorder?

This study explores the influence of avoidance behavior on the effectiveness of pharmacotherapy for panic disorder. The researchers analyzed data from 1134 patients who participated in a double-blind, randomized trial comparing alprazolam, imipramine, and placebo for panic disorder. The study found that patients with extensive avoidance behavior, often referred to as agoraphobia, benefited the most from active medications, particularly imipramine.

Avoidance Behavior and Panic Disorder Treatment

The study suggests that avoidance behavior, particularly agoraphobia, may be an important factor influencing the effectiveness of pharmacotherapy for panic disorder. The findings highlight the importance of addressing avoidance behaviors as part of a comprehensive treatment plan for panic disorder.

Health and Lifestyle Implications

This research underscores the critical role of addressing avoidance behavior in the treatment of panic disorder. It emphasizes the need for individualized treatment plans that consider the specific needs of patients, including their avoidance behaviors.

Dr.Camel's Conclusion

Think of avoidance behavior in panic disorder as a series of sand dunes that limit a person's ability to navigate the desert of their daily life. This research suggests that tackling those dunes head-on, using the right tools (medications), may be crucial to helping individuals with panic disorder feel more comfortable and confident moving forward. It's like clearing a path through the dunes, allowing them to explore more of the desert.

Date :
  1. Date Completed 1992-03-27
  2. Date Revised 2019-10-28
Further Info :

Pubmed ID

1790160

DOI: Digital Object Identifier

10.1007/BF02219714

Related Literature

Article Analysis
・Effective treatment of panic disorder
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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