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[Efficacy and safety of a reduced-dose of stavudine in HIV-infected patients under immunological and virological stable conditions].

Author: , ArazoPiedad, CartónJosé A, DeigElisabet, FloresJuan, JusdadoJuan-José, MartínTeodoro, PedrolEnric, RiberaEsteve, SanzJosé, del PozoMiguel Angel

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Overview

Reducing the dose of stavudine (d4T) in virologically and immunologically stable patients with HIV did not negatively impact treatment efficacy. The study showed that a d4T dose reduction may lead to improved safety profile, but further research with longer follow-up is needed to confirm this.
Paper Details　
Original Abstract of the Article :
BACKGROUND AND OBJECTIVE: Stavudine (d4T) has shown a favourable short and long-term tolerability profile. Nevertheless, its usage is currently decreasing due to some safety concerns. We aimed to evaluate the efficacy and safety of d4T low-dose-based regimens. PATIENTS AND METHOD: This was a multic...See full text at original site
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引用元：
https://doi.org/10.1157/13110209

データ提供：米国国立医学図書館（NLM）

Reduced-Dose Stavudine in HIV-Infected Patients: A Journey Through the Desert of HIV Treatment

[Stavudine (d4T)] is a vital weapon in the fight against [HIV], but like a desert oasis, its use can sometimes come with unintended consequences. This study explores the efficacy and safety of a reduced-dose regimen of d4T in patients with HIV who have achieved stable viral suppression.

Navigating the Desert of HIV Treatment: Balancing Efficacy and Safety

The study found that reducing the dose of d4T in patients with stable viral suppression did not compromise treatment efficacy. This finding suggests that a reduced-dose regimen may offer a way to minimize potential side effects while maintaining treatment effectiveness.

A Journey Through the Desert of HIV Treatment: Finding the Right Path

This research highlights the importance of individualized treatment approaches for patients with HIV. It suggests that careful monitoring and dose adjustments can help to optimize treatment outcomes while minimizing side effects.

Dr. Camel's Conclusion

This study offers a promising approach to managing d4T-related side effects while maintaining effective HIV treatment. The findings demonstrate that dose reduction can be a viable strategy for optimizing patient care.
Date :
  1. Date Completed 2007-12-28
  2. Date Revised 2019-08-23
Further Info :

Pubmed ID

17915129

DOI: Digital Object Identifier

10.1157/13110209

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Article Analysis
・Side Effects of d4t
SNS
PICO Info
in preparation
Languages

Spanish

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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