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Genotypic coreceptor analysis.

Author: KaiserR, LengauerT, SierraS, ThielenA

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

CCR5 blockers are a new class of antiretroviral drugs that block the CCR5 coreceptor, which is used by certain HIV strains. They can be used in clinical practice after determining the coreceptor usage of the virus. Genotypic systems can predict coreceptor usage, potentially enabling rapid screening for patients who could benefit from CCR5 blockers like Maraviroc.
Paper Details　
Original Abstract of the Article :
HIV infects target cells by binding of its envelope gp120 protein to CD4 and a coreceptor on the cell surface. In vivo, the different HIV-strains use either CCR5 or CXCR4 as coreceptor. CCR5-using strains are named R5 viruses, while CXCR4-using strains are named X4. X4 viruses usually occur in the l...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/17933727

データ提供：米国国立医学図書館（NLM）

HIV Coreceptor Analysis: A Crucial Tool for Personalized Treatment

In the battle against HIV, understanding the intricacies of viral infection is paramount. This article delves into the realm of coreceptor analysis, a crucial tool for tailoring HIV treatment strategies. HIV infects target cells by binding to CD4 and a coreceptor on the cell surface. The coreceptor usage, whether CCR5 or CXCR4, is a key determinant of disease progression and treatment options.

Genotypic and Phenotypic Analyses for Personalized Treatment

The article explores both genotypic and phenotypic methods for determining coreceptor usage. Genotypic methods utilize the amino acid sequence of the Env-V3 region of HIV-gp120 to predict coreceptor usage. Phenotypic assays, on the other hand, directly assess the viral strain's coreceptor preference. These analyses are crucial for guiding treatment decisions, particularly with the advent of coreceptor antagonists, drugs that block specific coreceptors.

Coreceptor Antagonists: A Promising Frontier in HIV Treatment

The article highlights the potential of coreceptor antagonists in HIV treatment. While CXCR4 blockers face challenges due to severe side effects, CCR5 blockers have shown promise and are now used clinically. The ability to predict coreceptor usage through genotypic analysis allows for targeted treatment with CCR5 blockers, potentially improving outcomes for individuals living with HIV.

Dr.Camel's Conclusion

The world of HIV treatment is vast and complex, like a shifting desert landscape. Coreceptor analysis acts as a compass, guiding us towards more personalized and effective treatment strategies. As researchers continue to explore new avenues, we can anticipate further advancements in the battle against HIV, ultimately leading to better health outcomes for those affected.

Date :
  1. Date Completed 2007-12-26
  2. Date Revised 2014-11-20
Further Info :

Pubmed ID

17933727

DOI: Digital Object Identifier

17933727

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English

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