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In vitro and ex vivo permeation studies of etodolac from hydrophilic gels and effect of terpenes as enhancers.

Author: OkyarAlper, OzkanYalcin, SavaserAyhan, TasCetin

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Etodolac, an anti-inflammatory drug, is commonly used to treat rheumatoid arthritis. However, it can cause gastrointestinal side effects. Topical formulations of etodolac with anethole, a terpene, may be an alternative to minimize gastrointestinal disturbances.
Paper Details　
Original Abstract of the Article :
Etodolac, a highly lipophilic anti-inflammatory drug, is widely used in rheumatoid arthritis usually at an oral dose of 200 mg twice daily. The commonest side effects during therapy with etodolac is generally gastrointestinal disturbances these are usually mild and reversible but in some patients ar...See full text at original site
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引用元：
https://doi.org/10.1080/10717540701603746

データ提供：米国国立医学図書館（NLM）

Improving Etodolac Delivery for Rheumatoid Arthritis

Etodolac, a commonly used anti-inflammatory drug, is often taken orally to treat rheumatoid arthritis, but it can cause stomach upset. This study explores using a topical gel formulation of etodolac to deliver the drug directly to the skin, minimizing the risk of gastrointestinal side effects. The researchers investigate different terpenes as enhancers for skin penetration.

Hydrophilic Gels Enhance Etodolac Delivery

The study found that hydrophilic gels containing anethole, a hydrophobic terpene, significantly improved the percutaneous absorption of etodolac. This suggests that topical gel formulations could offer an effective alternative to oral administration, potentially reducing gastrointestinal side effects.

A Promising Topical Approach to Rheumatoid Arthritis Treatment

This research offers a potential solution to the gastrointestinal side effects associated with oral etodolac. The study’s findings support the development of topical formulations as a safer and more effective way to deliver this important anti-inflammatory drug.

Dr. Camel's Conclusion

This study is like finding a cool spring oasis in the hot desert of gastrointestinal side effects. The findings suggest that topical etodolac gel formulations could offer a more comfortable and effective way to manage rheumatoid arthritis, minimizing the risk of digestive discomfort. This approach has the potential to improve the quality of life for patients living with this debilitating disease.

Date :
  1. Date Completed 2007-12-18
  2. Date Revised 2019-05-16
Further Info :

Pubmed ID

17994363

DOI: Digital Object Identifier

10.1080/10717540701603746

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・Side Effects of etodolac
SNS
PICO Info
in preparation
Languages

English

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