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Ovulatory response to treatment of polycystic ovary syndrome is associated with a polymorphism in the STK11 gene.

Author: , BarnhartHuiman X, CarrBruce R, CarsonSandra A, CataldoNicholas A, CoutifarisChristos, DiamondMichael P, EwensKathryn G, GiudiceLinda C, GosmanGabriella G, LegroRichard S, LeppertPhyllis C, McGovernPeter G, MyersEvan R, NestlerJohn E, SchlaffWilliam D, SpielmanRichard S, SteinkampfMichael P

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

This study found that a polymorphism in the STK11 gene is associated with ovulatory response to treatment with metformin in women with polycystic ovary syndrome. Women with the C allele of the polymorphism were less likely to ovulate than women with the G allele. Increased frequency of ovulation was also associated with lower body mass index, lower free androgen index, and a shorter duration of attempting conception.
Paper Details　
Original Abstract of the Article :
CONTEXT: Clomiphene and insulin sensitizers such as metformin are used to induce ovulation in polycystic ovary syndrome (PCOS), but the ovulatory response is variable, and the causes of this variation are poorly understood. OBJECTIVE: Our objective was to identify predictive genetic polymorphisms a...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266955/

データ提供：米国国立医学図書館（NLM）

PCOS and Ovulation: A Desert of Variability

Polycystic ovary syndrome (PCOS), like a desert landscape, is a condition marked by hormonal imbalances and a wide range of symptoms. This study, like a scientific expedition seeking to understand this complex terrain, investigates the genetic factors that influence ovulatory response to treatment in women with PCOS.

The STK11 Gene: A Key to Ovulation

The researchers, like skilled archeologists uncovering ancient secrets, identified a specific polymorphism in the STK11 gene that significantly affects ovulatory response to metformin treatment. This finding, like a hidden oasis in the desert, suggests that genetic factors, like the shifting sands, can play a crucial role in the effectiveness of PCOS treatments.

A Personalized Approach: Tailoring Treatment to the Individual

This research, like a well-equipped caravan navigating a challenging landscape, emphasizes the importance of individualized treatment approaches for PCOS. It suggests that genetic testing, like a compass guiding our journey, could help tailor treatment strategies to optimize outcomes for individual patients. This personalized approach, like a carefully planned route, could lead to better outcomes for women with PCOS.

Dr.Camel's Conclusion

This study, like a desert explorer uncovering a new route, sheds light on the complex interplay of genetics and treatment response in PCOS. The identification of the STK11 polymorphism, like a valuable treasure found in the desert, underscores the importance of personalized medicine in addressing this multifaceted condition. As we continue to explore the vast and varied landscape of PCOS, this research serves as a valuable guidepost for clinicians and researchers alike.
Date :
  1. Date Completed 2008-04-15
  2. Date Revised 2021-12-03
Further Info :

Pubmed ID

18000088

DOI: Digital Object Identifier

PMC2266955

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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