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Teriparatide or alendronate in glucocorticoid-induced osteoporosis.

Author: BoonenSteven, DalskyGail P, DonleyDavid W, MarcusRobert, MarínFernando, SaagKenneth G, ShaneElizabeth, TaylorKathleen A

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Teriparatide was more effective than alendronate in increasing bone mineral density and reducing the incidence of new vertebral fractures in patients with osteoporosis at high risk for fracture.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Bisphosphonate therapy is the current standard of care for the prevention and treatment of glucocorticoid-induced osteoporosis. Studies of anabolic therapy in patients who are receiving long-term glucocorticoids and are at high risk for fracture are lacking. METHODS: In an 18-month rand...See full text at original site
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引用元：
https://doi.org/10.1056/NEJMoa071408

データ提供：米国国立医学図書館（NLM）

A New Path for Glucocorticoid-Induced Osteoporosis: Teriparatide vs. Alendronate

This research delves into the complex realm of [glucocorticoid-induced osteoporosis], a significant health concern for individuals on long-term [glucocorticoid] therapy. The authors compare the efficacy of [teriparatide] and [alendronate] in preventing and treating [glucocorticoid-induced osteoporosis] in a [randomized, double-blind, controlled trial]. They aim to provide evidence-based insights for healthcare professionals, helping them navigate the challenging terrain of [glucocorticoid-induced osteoporosis] management.

Teriparatide Emerges as a Powerful Tool for Bone Health

The study indicates that [teriparatide] is more effective than [alendronate] in increasing [bone mineral density] at both the [lumbar spine] and [total hip] in individuals with [glucocorticoid-induced osteoporosis]. The study also reveals that [teriparatide] significantly reduces the incidence of [new vertebral fractures], offering a more comprehensive approach to managing the risks associated with [glucocorticoid-induced osteoporosis].

Building Strong Bones: A Journey Towards Improved Bone Health

The study’s findings offer valuable insights for individuals at risk for [glucocorticoid-induced osteoporosis]. The results demonstrate that [teriparatide] provides a more effective approach to increasing [bone mineral density] and reducing the risk of [fractures] compared to [alendronate]. This research underscores the importance of proactive bone health management and provides healthcare professionals with a valuable tool for preventing and treating [glucocorticoid-induced osteoporosis].

Dr.Camel's Conclusion

This research provides compelling evidence for the superiority of [teriparatide] over [alendronate] in managing [glucocorticoid-induced osteoporosis]. The study’s findings highlight the importance of considering anabolic therapies like [teriparatide] in individuals at high risk for [fractures]. The journey to maintaining strong bones is crucial for overall health and well-being, and this research offers a valuable tool for navigating this journey with greater confidence and hope.

Date :
  1. Date Completed 2007-11-21
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

18003959

DOI: Digital Object Identifier

10.1056/NEJMoa071408

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・Effective treatment of osteoporosis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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