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In vitro and in vivo effects of rh GM-CSF in acute myeloid leukemia (AML).

Author: BoeckmannA, FreireE A, FrischJ, HiddemannW, InnigG, ReuterC, RottmannR, SchulzG, WörmannB, ZühlsdorfM

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

A study of 36 patients with high-risk acute myeloid leukemia (AML) found that granulocyte-macrophage colony-stimulating factor (GM-CSF) treatment after chemotherapy reduced the time of critical neutropenia and improved complete remission rates compared to a historical control group. GM-CSF was also effective as a priming agent before chemotherapy.
Paper Details　
Original Abstract of the Article :
70% of patients with newly diagnosed and 50% of patients with relapsed acute myeloid leukemia (AML) can achieve a complete remission with intensive chemotherapy. However, the treatment-associated mortality can be as high as 30% increasing with age, previous chemotherapy and intensity of chemotherapy...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/1801688

データ提供：米国国立医学図書館（NLM）

rhGM-CSF: A Potential Oasis in the Desert of Acute Myeloid Leukemia

Acute myeloid leukemia (AML), a type of cancer affecting the blood and bone marrow, can be a challenging and often aggressive disease. This research explores the potential of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) as a supportive therapy for AML patients. The study examines the effects of rhGM-CSF on AML patients, investigating its role in reducing treatment toxicity and improving overall treatment outcomes.

A Hopeful Oasis: rhGM-CSF Shows Potential

The study found that rhGM-CSF showed promising results in AML patients, potentially reducing treatment-associated mortality and improving complete remission rates. The researchers concluded that rhGM-CSF could play a valuable role in managing AML, offering a potential oasis in the desert of this challenging disease.

A Collaborative Approach: Fighting Leukemia with Multiple Tools

This research highlights the importance of utilizing a multifaceted approach to managing AML, emphasizing the potential of rhGM-CSF as a valuable tool in the arsenal against this formidable disease. It's like finding a collaborative oasis in the desert of cancer treatment, where different therapies work together to overcome the challenges of this complex condition.

Dr. Camel's Conclusion

This research investigates the potential of rhGM-CSF as a supportive therapy for AML patients. The study demonstrates its potential to reduce treatment toxicity and improve complete remission rates, suggesting that rhGM-CSF could play a significant role in managing this complex and often aggressive disease.

Date :
  1. Date Completed 1992-04-21
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

1801688

DOI: Digital Object Identifier

1801688

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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