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Neuropsychological and neurophysiologic effects of carbamazepine and levetiracetam.

Author: BaumC, EvansB M, GevinsA, LoringD W, McEvoyL K, MeadorK J, MotamediG K, RayP G, SmithM E

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

Levetiracetam (LEV) produced fewer untoward neuropsychological and neurophysiologic effects than carbamazepine (CBZ) in healthy adults.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The relative effects of levetiracetam (LEV) and carbamazepine (CBZ) on cognitive and neurophysiologic measures are uncertain. METHODS: The effects of LEV and CBZ were compared in healthy adults using a randomized, double-blind, two-period crossover design. Outcome measures included 11 s...See full text at original site
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引用元：
https://doi.org/10.1212/01.wnl.0000281104.55418.60

データ提供：米国国立医学図書館（NLM）

Carbamazepine and Levetiracetam: A Cognitive Comparison

Antiepileptic drugs (AEDs) are essential for controlling seizures, but they can have side effects that impact cognitive function. This study compares the cognitive and neurophysiological effects of two common AEDs: carbamazepine (CBZ) and levetiracetam (LEV). The researchers conducted a randomized, double-blind, crossover study involving healthy adults who received either CBZ or LEV for a period of four weeks. They assessed various cognitive measures and neurophysiological parameters related to attention and memory.

Navigating the Cognitive Desert

The study found that CBZ had a greater negative impact on cognitive function compared to LEV, suggesting that LEV may be a better choice for patients who are concerned about cognitive side effects. The researchers also observed differences in the effects of both drugs on specific cognitive domains, providing valuable insights into their potential impact on cognitive function.

Cognitive Health and AEDs

The study findings highlight the importance of considering the potential cognitive effects of AEDs when making treatment decisions. The research suggests that LEV may be a better choice than CBZ for patients who are sensitive to cognitive side effects.

Dr.Camel's Conclusion

This study provides valuable insights into the comparative cognitive effects of carbamazepine and levetiracetam, two common antiepileptic drugs. The findings suggest that levetiracetam may be a better option for patients who are concerned about cognitive side effects. The research emphasizes the importance of considering the potential cognitive impact of AEDs when making treatment decisions, particularly for individuals who rely on optimal cognitive function in their daily lives.

Date :
  1. Date Completed 2007-12-26
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

18040014

DOI: Digital Object Identifier

10.1212/01.wnl.0000281104.55418.60

SNS
PICO Info
in preparation
Languages

English

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