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[Neoadjuvant endocrine therapy for locally advanced breast cancer].

Author: ContiF, LopezM, SergiD, ViolaG

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Overview

This study explores the use of hormone therapy (endocrine therapy) as a treatment option for locally advanced breast cancer in postmenopausal women. While chemotherapy is commonly used, hormone therapy is considered a viable alternative for tumors that respond to hormones, particularly for older or frail patients. The study reviews research comparing different hormone therapies (tamoxifen and aromatase inhibitors) and their effectiveness, finding that aromatase inhibitors, like letrozole, may be more effective than tamoxifen in shrinking tumors. The study emphasizes the need for further research to determine the optimal hormone therapy and suggests that hormone therapy may be a good option for specific patients, such as those who are older, have tumors that are not operable, or cannot tolerate chemotherapy.
Paper Details　
Original Abstract of the Article :
The use of neoadjuvant chemotherapy in the treatment of locally advanced breast cancer is now well established. However, endocrine therapy can be a valid alternative to primary chemotherapy in the treatment of hormone-sensitive tumors, particularly in post-menopausal women. Tamoxifen (TAM) was initi...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/18062352

データ提供：米国国立医学図書館（NLM）

Neoadjuvant Endocrine Therapy for Locally Advanced Breast Cancer: A Promising Alternative

The treatment landscape for locally advanced breast cancer has been steadily evolving, and endocrine therapy is emerging as a significant player, particularly for hormone-sensitive tumors. This research delves into the use of neoadjuvant endocrine therapy, a treatment strategy that aims to shrink the tumor before surgery. The study focuses on the comparative efficacy of various endocrine agents, including tamoxifen and aromatase inhibitors, in terms of tumor response and their impact on surgical options. The findings provide valuable insights into the potential of endocrine therapy as a viable alternative to traditional chemotherapy, particularly for postmenopausal women.

Aromatase Inhibitors: A New Oasis in Breast Cancer Treatment

The study found that certain aromatase inhibitors, such as letrozole, demonstrated superior efficacy compared to tamoxifen in terms of tumor response and breast-conserving surgery rates. This discovery paves the way for personalized treatment approaches, tailoring therapy to specific patient characteristics and tumor biology. The potential for less invasive surgery and improved patient outcomes is a significant advancement in breast cancer management.

Empowering Patients with Knowledge: A Journey Through the Desert

This research emphasizes the importance of ongoing research to optimize breast cancer treatment. As healthcare professionals, we must continually learn and adapt to ensure the best possible outcomes for our patients. Like a desert traveler, we must remain open to new discoveries and embrace the potential of innovative therapies. Empowering patients with knowledge and providing access to personalized care is key to navigating the complex journey of battling this disease.

Dr. Camel's Conclusion

This study demonstrates the power of research in pushing the boundaries of what we know about breast cancer treatment. The emergence of aromatase inhibitors as effective alternatives to traditional chemotherapy is a significant step forward. We must continue to explore new treatment options and personalized approaches to ensure the best possible outcomes for our patients. Like a resilient camel adapting to the harsh desert environment, we must embrace change and strive for continuous improvement in the face of this challenging disease.

Date :
  1. Date Completed 2008-02-07
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

18062352

DOI: Digital Object Identifier

18062352

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・Effective treatment of breast cancer
SNS
PICO Info
in preparation
Languages

Italian

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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