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A randomized double-blind comparison of ziprasidone vs. clozapine for cognition in patients with schizophrenia selected for resistance or intolerance to previous treatment.

Author: BilderRobert M, GalluzzoAlessandro, GoriniBarbara, HarveyPhilip D, LoebelAntony D, RomeoFabio, SacchettiEmilio

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study compared the cognitive benefits of clozapine and ziprasidone in schizophrenia patients who had failed to respond to or were intolerant of other antipsychotics.
Paper Details　
Original Abstract of the Article :
Recent data have suggested few differences in the cognitive effects of antipsychotic medications. However, assessment of such effects can be complex, due to a number of factors. Clozapine has previously shown greater clinical and lesser cognitive benefits than other atypicals. This study compared th...See full text at original site
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引用元：
https://doi.org/10.1016/j.schres.2007.11.014

データ提供：米国国立医学図書館（NLM）

Ziprasidone vs. Clozapine: Cognitive Effects in Schizophrenia Patients

Schizophrenia, a complex mental illness, often presents significant challenges for patients and clinicians. This study compares the cognitive effects of two antipsychotic medications, ziprasidone and clozapine, in schizophrenia patients who haven't responded well to previous treatments. The researchers, like skilled cartographers mapping the intricate terrain of the human mind, investigated the cognitive impact of these medications on patients with schizophrenia.

Cognitive Effects of Antipsychotic Medications in Schizophrenia

The study investigates the cognitive effects of ziprasidone and clozapine in schizophrenia patients, offering insights into the potential benefits and limitations of these medications. This research, like a meticulously crafted compass guiding us through the complexities of mental illness, provides valuable information for clinicians seeking to optimize treatment strategies for patients with schizophrenia.

Understanding the Cognitive Impact of Antipsychotic Medications

This study, like a desert oasis providing respite from the harsh realities of mental illness, offers a glimpse into the cognitive effects of antipsychotic medications in schizophrenia. The authors' findings highlight the importance of considering the cognitive impact of medications when treating patients with schizophrenia, ensuring that treatment plans are tailored to their individual needs.

Dr.Camel's Conclusion

This research, like a wise and experienced camel guide leading a caravan through the challenging desert of schizophrenia, reminds us of the importance of understanding the complex interplay between medication, cognition, and mental health. The study's findings encourage further research into the cognitive effects of antipsychotic medications, paving the way for more personalized and effective treatment strategies for patients with schizophrenia.

Date :
  1. Date Completed 2008-12-11
  2. Date Revised 2022-03-17
Further Info :

Pubmed ID

18077136

DOI: Digital Object Identifier

10.1016/j.schres.2007.11.014

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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