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Dose effects of continuous vinblastine chemotherapy on mammalian angiogenesis mediated by VEGF-A.
Author: AlbertssonPer, LennernäsBo, NorrbyKlas
Original Abstract of the Article :
Low-dose continuous or metronomic chemotherapy with several agents can exert significant antiangiogenic effects, as shown in preclinical studies. Therapy of this kind is generally well tolerated compared with conventional chemotherapy with high, temporally spaced out bolus doses. A critical point em...See full text at original site
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引用元:
https://doi.org/10.1080/02841860701558781
データ提供:米国国立医学図書館(NLM)
Unraveling the Dose-Dependent Effects of Vinblastine Chemotherapy on Angiogenesis
The [cancer] landscape is a complex and challenging terrain, with researchers constantly seeking new strategies to combat this formidable disease. This study, like a team of scientists delving into the mysteries of the desert, investigated the [dose-dependent] effects of [vinblastine chemotherapy] on [angiogenesis], the process of blood vessel formation that fuels tumor growth.
The researchers, like skilled explorers charting a new route, employed a [metronomic chemotherapy] approach, administering continuous low doses of vinblastine to [tumor-free rat mesentery]. Their findings, like a well-mapped oasis in the desert, revealed a [dose-response relationship], demonstrating that higher doses of vinblastine were more effective in suppressing angiogenesis. This discovery, like a hidden spring in the desert, offers valuable insights into the potential of optimizing vinblastine dosing for more effective cancer treatment.
The Importance of Optimizing Chemotherapy Dosing
The study's findings underscore the importance of finding the [optimal dose] of chemotherapy drugs to maximize their effectiveness while minimizing side effects. This approach, like a camel carefully navigating a sandstorm, ensures that we achieve our destination with the least amount of damage. This research serves as a crucial guide for healthcare professionals as they seek to personalize cancer treatments.
Optimizing Chemotherapy for Better Outcomes
This research reminds us that, like the shifting sands of the desert, our understanding of cancer treatment is constantly evolving. Finding the right dose of chemotherapy drugs is crucial for achieving better outcomes. This approach, like a wise caravan selecting the best path across the dunes, prioritizes both effectiveness and safety for patients.
Dr.Camel's Conclusion
This study highlights the importance of finding the optimal dose of vinblastine chemotherapy for effective suppression of angiogenesis. It underscores the need for personalized treatment approaches that consider individual patient needs and responses to medication, ultimately leading to better cancer treatment outcomes.
Date :
- Date Completed 2008-05-29
- Date Revised 2013-11-21
Further Info :
Related Literature
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