Paper Details

  1. Home
  2. Paper Details

A double-blind gastroscopic evaluation of the effects of etodolac and naproxen on the gastrointestinal mucosa of rheumatic patients.

Author: ArdizzoneS, Bianchi PorroG, CarusoI, MontroneF, PetrilloM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Etodolac, a new non-steroidal anti-inflammatory drug, was found to be at least as effective as naproxen in relieving rheumatic symptoms, but caused significantly less gastric damage. In a study of 48 patients with rheumatoid arthritis, 15% of etodolac-treated patients experienced gastric mucosal lesions compared to 46% of patients treated with naproxen. Etodolac also caused less dyspepsia (15% vs 38%).
Paper Details　
Original Abstract of the Article :
The aim of this clinical, endoscopical study was to evaluate the therapeutic efficacy and the gastric tolerability of etodolac, a new anti-inflammatory, non-steroidal drug, compared with naproxen. The study was conducted on 48 patients suffering from rheumatoid arthritis. 44 of whom completed the tr...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1111/j.1365-2796.1991.tb00298.x

データ提供：米国国立医学図書館（NLM）

Etodolac vs. Naproxen: A Gastroscopic Comparison in Rheumatoid Arthritis

Navigating the vast desert of pain management, we often find ourselves seeking effective and tolerable treatments for chronic conditions like rheumatoid arthritis. This study compares two non-steroidal anti-inflammatory drugs (NSAIDs), etodolac and naproxen, for their effectiveness and impact on the gastrointestinal tract.

The study aims to evaluate the therapeutic efficacy and gastric tolerability of etodolac compared to naproxen in patients with rheumatoid arthritis. The researchers used endoscopy, a procedure that allows visualization of the gastrointestinal tract, to assess the effects of these drugs on the stomach lining.

A Tale of Two NSAIDs: Different Footprints in the Desert

The study found that both etodolac and naproxen were effective in relieving rheumatoid arthritis symptoms. However, etodolac was associated with significantly less gastrointestinal damage compared to naproxen. This finding is crucial, as it suggests that etodolac may be a safer option for patients at risk of gastrointestinal complications.

Navigating the Desert of NSAID Use: A Guide for Patients

For patients with rheumatoid arthritis, this study highlights the importance of discussing potential side effects and risks with their healthcare provider. It is crucial to choose an NSAID that balances effectiveness with safety, considering individual factors like gastrointestinal health.

Dr. Camel's Conclusion

This study reveals that etodolac may be a more gastrointestinal-friendly option than naproxen for patients with rheumatoid arthritis. It underscores the importance of careful medication selection and patient education to ensure optimal outcomes and minimize potential side effects.
Date :
  1. Date Completed 1991-03-22
  2. Date Revised 2019-09-03
Further Info :

Pubmed ID

1825323

DOI: Digital Object Identifier

10.1111/j.1365-2796.1991.tb00298.x

Related Literature

Article Analysis
・Effects of etodolac
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.