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Nucleoside analogue reverse transcriptase inhibitors differentially inhibit human LINE-1 retrotransposition.

Author: DuanErick H, GarrisonKeith E, JonesR Brad, NixonDouglas F, OstrowskiMario A, WongJessica C

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study discusses the role of LINE-1 elements, retrotransposons capable of autonomous replication, in genetic disease, oncogenesis, and normal physiology.
Paper Details　
Original Abstract of the Article :
Intact LINE-1 elements are the only retrotransposons encoded by the human genome known to be capable of autonomous replication. Numerous cases of genetic disease have been traced to gene disruptions caused by LINE-1 retrotransposition events in germ-line cells. In addition, genomic instability resul...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212136/

データ提供：米国国立医学図書館（NLM）

LINE-1 Retrotransposons: A Double-Edged Sword in Human Genetics

LINE-1 elements are a type of retrotransposon, which are genetic sequences that can move around within the genome. This study investigates the effects of nucleoside analogue reverse transcriptase inhibitors (NARTIs), commonly used to treat HIV infection, on the activity of LINE-1 retrotransposons. The researchers found that NARTIs can differentially inhibit the activity of LINE-1 retrotransposons. This finding is significant because LINE-1 retrotransposons have been implicated in various genetic diseases, including cancer. The research provides valuable insights into the potential interactions between antiretroviral medications and human retrotransposons.

NARTIs: A Potential Impact on LINE-1 Retrotransposons

The study's findings highlight the potential impact of NARTIs on the activity of LINE-1 retrotransposons. This suggests that NARTIs could potentially have broader implications for human health beyond their role in HIV treatment.

Navigating the Complexities of the Genome

This research underscores the complex interplay between genetic elements and pharmaceutical interventions. It's essential to be aware of the potential interactions between medications and the genome, as these interactions can have significant implications for human health.

Dr. Camel's Conclusion

This study offers a fascinating glimpse into the complex world of retrotransposons and their potential impact on human health. The research highlights the need for further investigation into the interactions between medications and the genome, ensuring patient safety and optimizing treatment outcomes.

Date :
  1. Date Completed 2008-07-15
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

18253495

DOI: Digital Object Identifier

PMC2212136

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