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Effects of quinapril on exercise tolerance in patients with mild to moderate heart failure.

Author: RieggerG A

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Quinapril, a non-sulfhydryl angiotensin converting enzyme inhibitor, significantly improved exercise tolerance and symptoms in 225 patients with mild to moderate heart failure. The improvement was dose-related and sustained over 12 months, with no serious side effects.
Paper Details　
Original Abstract of the Article :
The objective of this double-blind, placebo-controlled, randomized multicentre study was to determine whether treatment with the new non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor quinapril, as an addition to maintenance therapy with digitalis and/or diuretics, would improve exercise t...See full text at original site
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引用元：
https://doi.org/10.1093/eurheartj/12.6.705

データ提供：米国国立医学図書館（NLM）

Effects of Quinapril on Exercise Tolerance in Patients with Mild to Moderate Heart Failure

This double-blind, placebo-controlled, randomized multicentre study examines the effects of quinapril, a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor, on exercise tolerance in patients with mild to moderate heart failure. The researchers compared the effects of quinapril to placebo in four treatment groups, observing a significant improvement in exercise time with quinapril therapy. The study found that quinapril significantly improved exercise tolerance in patients with mild to moderate heart failure, suggesting its potential as a valuable treatment option for this condition.

Quinapril: A Potential Treatment for Improving Exercise Tolerance in Heart Failure

This research highlights the beneficial effects of quinapril on exercise tolerance in patients with mild to moderate heart failure. The study demonstrates that quinapril significantly improves exercise time, suggesting that it may be a valuable treatment option for improving functional capacity and quality of life in these patients. This research offers a promising avenue for improving the lives of individuals living with heart failure.

Heart Failure Management: Enhancing Quality of Life

This study underscores the importance of addressing the functional limitations associated with heart failure. Just as a camel adapts its gait to navigate challenging terrain, patients with heart failure often need to adapt their daily activities to manage their condition. This research offers a glimmer of hope for improving exercise tolerance and enhancing quality of life for individuals living with heart failure, providing them with the tools to navigate the challenging landscape of their condition.

Dr. Camel's Conclusion

This double-blind, placebo-controlled, randomized multicentre study provides compelling evidence for the effectiveness of quinapril in improving exercise tolerance in patients with mild to moderate heart failure. The findings suggest that quinapril may be a valuable treatment option for improving functional capacity and quality of life in these patients. As a camel who has witnessed the resilience of life in the desert, I am inspired by the potential of medications like quinapril to improve the lives of individuals facing challenging health conditions. This research offers a beacon of hope for those living with heart failure, paving the way for a brighter and more active future.
Date :
  1. Date Completed 1991-09-04
  2. Date Revised 2019-05-10
Further Info :

Pubmed ID

1830551

DOI: Digital Object Identifier

10.1093/eurheartj/12.6.705

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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