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The development of topically acting carbonic anhydrase inhibitors as antiglaucoma agents.

Author: MincioneFrancesco, ScozzafavaAndrea, SupuranClaudiu T

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Carbonic anhydrase inhibitors (CAIs) are used for the treatment of glaucoma, a condition characterized by elevated intraocular pressure (IOP). Topical CAIs, such as dorzolamide and brinzolamide, are more effective and have fewer side effects than systemic CAIs. Research is ongoing to develop more effective topical CAIs.
Paper Details　
Original Abstract of the Article :
Inhibition of carbonic anhydrase (CA, EC 4.2.1.1) isoforms present in the eyes (CA I, II, IV and XII), with sulfonamides such as acetazolamide, methazolamide, ethoxzolamide and dichlorophenamide, is still widely used for the systemic treatment of glaucoma. The mechanism of action of these drugs cons...See full text at original site
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引用元：
https://doi.org/10.2174/138161208783877866

データ提供：米国国立医学図書館（NLM）

Topically Acting Carbonic Anhydrase Inhibitors as Antiglaucoma Agents

This study focuses on the development of topically acting carbonic anhydrase inhibitors (CAIs) as a treatment for glaucoma, a condition characterized by elevated intraocular pressure. The research explores the challenges associated with systemic CAIs, highlighting their potential side effects due to the widespread presence of CA isoforms in various tissues. The study emphasizes the development of topically effective CAIs, which are applied directly to the eye, minimizing systemic exposure and side effects. The research highlights the efficacy of dorzolamide and brinzolamide, two clinically available topical CAIs, in reducing intraocular pressure. The study also discusses ongoing research efforts to develop even more effective and well-tolerated topical CAIs, offering a potential breakthrough in glaucoma management.

A Targeted Approach to Glaucoma Treatment

This study presents a targeted approach to glaucoma treatment, focusing on the development of topically effective carbonic anhydrase inhibitors (CAIs). The research highlights the importance of minimizing systemic exposure and side effects by delivering the medication directly to the eye, offering a more patient-friendly treatment option. Imagine this research as a desert oasis, providing a focused and effective treatment approach for those affected by glaucoma.

Improved Treatment Options for Glaucoma

This study explores the potential for improved treatment options for glaucoma. By developing more effective and well-tolerated topical CAIs, the research could lead to better outcomes for patients, potentially reducing the risk of vision loss. It's like a desert well, providing a steady and reliable source of relief for those struggling with glaucoma.

Dr.Camel's Conclusion

This study delves into the development of topically acting carbonic anhydrase inhibitors (CAIs) as a treatment for glaucoma. The research highlights the potential benefits of topical CAIs, offering a more targeted and patient-friendly approach to managing this condition. It's a testament to the ongoing efforts in ophthalmological research, seeking to improve the lives of those affected by vision disorders.
Date :
  1. Date Completed 2008-04-18
  2. Date Revised 2022-03-16
Further Info :

Pubmed ID

18336310

DOI: Digital Object Identifier

10.2174/138161208783877866

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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