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Double-blind placebo-controlled trial of amitriptyline for the treatment of irritable bowel syndrome in adolescents.

Author: AmentMarvin E, BaharRon J, CollinsBrynie S, SteinmetzBarry

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Amitriptyline (AMI) significantly improved overall quality of life in adolescents with irritable bowel syndrome (IBS). Patients taking AMI were more likely to experience improvement in their quality of life at 6, 10, and 13 weeks. They were also more likely to experience a reduction in IBS-associated diarrhea, periumbilical pain, and right lower quadrant pain.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: To determine the efficacy of amitriptyline (AMI) in treating irritable bowel syndrome (IBS) in adolescents. STUDY DESIGN: Adolescents 12 to 18 years with newly diagnosed IBS were surveyed with a symptom checklist, pain rating scale, visual analog scale, and IBS quality of life (QOL) que...See full text at original site
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引用元：
https://doi.org/10.1016/j.jpeds.2007.10.012

データ提供：米国国立医学図書館（NLM）

Amitriptyline for Irritable Bowel Syndrome in Adolescents: A New Oasis in the Desert of Digestive Distress

Irritable bowel syndrome (IBS) is a common condition, often leaving individuals feeling like they are lost in a desert of digestive distress. This research explores the potential of amitriptyline (AMI) as a treatment for IBS in adolescents, investigating its efficacy in improving symptoms and quality of life. The authors conducted a double-blind placebo-controlled trial, enrolling 33 adolescents with newly diagnosed IBS.

Hope for Adolescents with IBS: Amitriptyline Shows Promise

The results demonstrate that AMI significantly improves overall quality of life in adolescents with IBS. The authors found that adolescents receiving AMI were more likely to experience improvements in their quality of life, as well as reductions in various IBS-associated symptoms, including diarrhea and abdominal pain. This suggests that AMI could be a valuable treatment option for adolescents struggling with IBS.

Navigating the Desert of IBS: Finding Relief for Adolescents

This research offers hope for adolescents battling IBS, suggesting that AMI could provide relief from symptoms and improve their quality of life. It emphasizes the need for further research to fully understand the long-term effects of AMI and its role in managing IBS in this population. This research is a valuable step forward in addressing the needs of adolescents with IBS, paving the way for more effective treatments and improved outcomes.

Dr.Camel's Conclusion

This research offers valuable insights into the potential of AMI as a treatment for IBS in adolescents. It provides hope for individuals struggling with this common and often debilitating condition, highlighting the importance of finding effective treatments that improve quality of life. This research is a reminder that even in the most challenging of health conditions, there is often a path to relief, and the quest for better treatments continues.

Date :
  1. Date Completed 2008-05-06
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

18410774

DOI: Digital Object Identifier

10.1016/j.jpeds.2007.10.012

Related Literature

Article Analysis
・Effective treatment of irritable bowel syndrome
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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