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Comparison of the cardiac electrophysiological effects between doxazosin and bunazosin.

Author: ChenWen-Pin, LeeAn-Sheng, SuMing-Jai

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Doxazosin, an alpha-1 adrenoceptor blocker, can cause heart rhythm problems at higher doses, while bunazosin, another alpha-1 blocker, is safer for long-term use.
Paper Details　
Original Abstract of the Article :
In Langendorff-perfused adult rat heart with constant pressure at 80 mmHg, we found doxazosin, an alpha(1) adrenoceptor blocker, at 10 muM prolonged PR interval and induced occasional arrhythmia followed by complete inhibition of the sinus rhythm, whereas bunazosin, another alpha(1)-blocker, at same...See full text at original site
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引用元：
https://doi.org/10.1007/s11373-008-9249-8

データ提供：米国国立医学図書館（NLM）

Comparison of Cardiac Electrophysiological Effects

This study compares the cardiac electrophysiological effects of two alpha-1 adrenoceptor blockers, doxazosin and bunazosin. It's like examining two different paths through the desert of the heart's electrical system, seeking to understand their impact on heart function. The researchers aim to determine the relative safety of these drugs for long-term use.

Understanding the Effects of Alpha-Blockers

The study reveals that doxazosin, at higher concentrations, can prolong the PR interval and induce arrhythmias, while bunazosin does not have these effects. This finding is like discovering a hidden pitfall on one path through the desert – a warning sign to proceed with caution. The researchers suggest that bunazosin may be a safer option for long-term treatment due to its more favorable electrophysiological profile.

Implications for Cardiovascular Health

This research provides valuable insights into the potential risks and benefits of different alpha-blockers for cardiovascular health. It's like finding a reliable guide who can warn of potential hazards in the desert and suggest safer routes. The findings could help clinicians choose the most appropriate medication for their patients, minimizing the risk of adverse cardiac events.

Dr.Camel's Conclusion

This study highlights the importance of understanding the intricate workings of the cardiovascular system. It's like mapping out a vast and complex desert, revealing the pathways and potential obstacles that influence heart function. This research underscores the need for careful evaluation of medications to ensure they are safe and effective for long-term use.
Date :
  1. Date Completed 2008-08-08
  2. Date Revised 2014-11-20
Further Info :

Pubmed ID

18427952

DOI: Digital Object Identifier

10.1007/s11373-008-9249-8

Related Literature

Article Analysis
・Side Effects of doxazosin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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