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Calcium modulation of toxicities due to Cisplatin.

Author: AggarwalS K

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Cisplatin (CDDP) is a potent anti-neoplastic agent that can cause gastrointestinal and nephrotoxicity. This study evaluated the effect of CDDP on various dehydrogenases and nonspecific lipase enzymes in dogs. Calcium supplements were found to have a protective effect against CDDP toxicity.
Paper Details　
Original Abstract of the Article :
Cisplatin (CDDP) is a potent anti-neoplastic agent with associated toxicities, especially gastrointestinal and nephrotoxicity that are its dose-limiting factors in clinical oncology. In an attempt to elucidate its mechanism(s) of action, liver and kidney tissues from normal and CDDP treated (1.8 mg/...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365104/

データ提供：米国国立医学図書館（NLM）
in preparation
Date :
  1. Date Completed 2011-07-14
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

18475826

DOI: Digital Object Identifier

PMC2365104

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Languages

English

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