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Calcium modulation of toxicities due to Cisplatin.

Author: AggarwalS K

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Cisplatin (CDDP) is a potent anti-neoplastic agent that can cause gastrointestinal and nephrotoxicity. This study evaluated the effect of CDDP on various dehydrogenases and nonspecific lipase enzymes in dogs. Calcium supplements were found to have a protective effect against CDDP toxicity.
Paper Details　
Original Abstract of the Article :
Cisplatin (CDDP) is a potent anti-neoplastic agent with associated toxicities, especially gastrointestinal and nephrotoxicity that are its dose-limiting factors in clinical oncology. In an attempt to elucidate its mechanism(s) of action, liver and kidney tissues from normal and CDDP treated (1.8 mg/...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365104/

データ提供：米国国立医学図書館（NLM）

Calcium Modulation of Cisplatin Toxicities: A Desert Oasis of Protection

This study takes us into the world of chemotherapy, a challenging landscape where powerful drugs are used to combat cancer cells. The study focuses on the toxicities associated with Cisplatin, a potent anti-neoplastic agent that is like a desert wind, blowing through the body with both positive and negative effects. The researchers investigate the role of calcium in mitigating the toxicities of Cisplatin, particularly in the gastrointestinal and nephrotoxic areas. The study found that calcium supplementation can help protect against the damaging effects of Cisplatin, acting like a protective oasis in the desert of chemotherapy side effects.

A New Oasis in the Desert of Chemotherapy

This research suggests that calcium supplementation could be a valuable tool for managing the toxicities associated with Cisplatin. This approach offers a potential strategy to mitigate the side effects of this powerful drug.

Navigating the Desert of Cancer Treatment

Individuals undergoing chemotherapy should discuss potential risks and side effects with their healthcare providers. Understanding the role of calcium supplementation and other strategies for managing toxicities can help patients navigate the challenges of cancer treatment.

Dr.Camel's Conclusion

This study offers a promising avenue for mitigating the toxicities associated with Cisplatin. The findings highlight the potential of calcium supplementation as a valuable tool for protecting against the damaging effects of chemotherapy.

Date :
  1. Date Completed 2011-07-14
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

18475826

DOI: Digital Object Identifier

PMC2365104

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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