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Subjective, psychomotor, and physiological effects profile of hydrocodone/acetaminophen and oxycodone/acetaminophen combination products.

Author: GutierrezSandra, ZacnyJames P

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

In a study of 16 healthy volunteers, oxycodone/acetaminophen produced a wider spectrum of subjective effects than hydrocodone/acetaminophen at the 10 mg opioid dose. Both drug combinations impaired psychomotor performance at the 10 mg opioid dose.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: To compare within the same individuals two typically prescribed doses of hydrocodone/acetaminophen and oxycodone/acetaminophen products for their subjective, psychomotor, and physiological effects in healthy volunteers. DESIGN: A randomized, placebo-controlled, double-blind, crossover, ...See full text at original site
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引用元：
https://doi.org/10.1111/j.1526-4637.2007.00359.x

データ提供：米国国立医学図書館（NLM）

Comparing Opioids: A Look at Subjective and Psychomotor Effects

This study explores the subjective, psychomotor, and physiological effects of two commonly prescribed opioid/acetaminophen combination products: hydrocodone/acetaminophen and oxycodone/acetaminophen. The research compares the effects of different doses of these products in healthy volunteers, providing insights into the potential differences in their subjective and psychomotor effects. This research offers valuable information for healthcare professionals prescribing these medications.

A Tale of Two Opioids: Distinct Subjective and Psychomotor Effects

The study reveals significant differences in subjective effects between the two opioid combinations, particularly at higher doses. Oxycodone/acetaminophen produced a wider spectrum of subjective effects, including drowsiness, dizziness, and mood alterations, compared to hydrocodone/acetaminophen. The research highlights the importance of considering these differences in patient education and monitoring. This research underscores the need for individualized prescribing practices, taking into account the unique characteristics of each opioid medication.

Navigating Opioid Therapy: Patient Safety and Informed Decision-Making

The study emphasizes the importance of patient education and informed decision-making regarding opioid therapy. Healthcare professionals should discuss the potential subjective and psychomotor effects of opioid medications with patients, particularly those involved in activities that require alertness and coordination. This research highlights the need for a patient-centered approach to opioid therapy, ensuring patient safety and optimal outcomes.

Dr.Camel's Conclusion

Just as a desert landscape is composed of diverse terrains, the world of opioid medications presents a range of effects. This research provides valuable insights into the subjective and psychomotor effects of two commonly prescribed opioid combinations, highlighting the importance of individualized prescribing practices and patient education. By understanding the nuances of opioid therapy, we can strive to ensure patient safety and optimize treatment outcomes.

Date :
  1. Date Completed 2008-07-07
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

18489634

DOI: Digital Object Identifier

10.1111/j.1526-4637.2007.00359.x

SNS
PICO Info
in preparation
Languages

English

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