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Anticholinergic activity of 107 medications commonly used by older adults.

Author: BiesRobert R, ChewMarci L, GharabawiGeorges, GreenspanAndrew, KirshnerMargaret A, LehmanMark E, MahmoudRamy A, MulsantBenoit H, PollockBruce G, SorisioDenise A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study measured the anticholinergic activity of 107 medications commonly used by older adults. The study found that many medications, particularly psychotropic medications, have anticholinergic activity. This information can help clinicians choose medications that are less likely to cause anticholinergic side effects.
Paper Details　
Original Abstract of the Article :
The objective of this study was to measure the anticholinergic activity (AA) of medications commonly used by older adults. A radioreceptor assay was used to investigate the AA of 107 medications. Six clinically relevant concentrations were assessed for each medication. Rodent forebrain and striatum ...See full text at original site
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引用元：
https://doi.org/10.1111/j.1532-5415.2008.01737.x

データ提供：米国国立医学図書館（NLM）

Anticholinergic Activity of Medications: Navigating the Side Effects

Many medications, like hidden dangers in the desert, can have unintended consequences. This study, published in the Journal of the American Geriatrics Society, investigated the anticholinergic activity (AA) of 107 medications commonly used by older adults. Anticholinergic medications block the action of acetylcholine, a neurotransmitter that plays a crucial role in various bodily functions, including memory, muscle control, and heart rate.

Anticholinergic Medications: A Potential Risk for Older Adults

The study found that several medications, particularly psychotropic drugs, showed significant anticholinergic activity at therapeutic doses. This can lead to a range of side effects, including confusion, memory problems, constipation, dry mouth, and urinary retention. These side effects can be particularly problematic for older adults, who are already more susceptible to age-related cognitive decline and physical limitations.

Choosing Medications Wisely: Protecting Cognitive Function

This study underscores the importance of carefully considering the potential anticholinergic effects of medications, especially for older adults. Healthcare professionals should be mindful of the overall anticholinergic burden, considering the combined effects of all medications a patient is taking. Just as a desert traveler needs to conserve water, individuals should be mindful of the potential for anticholinergic medications to deplete their cognitive reserves.

Dr. Camel's Conclusion

This study serves as a valuable reminder that even seemingly safe medications can have unintended consequences. It highlights the importance of careful medication selection, especially for older adults, and the need to minimize the overall anticholinergic burden. Navigating the desert of medication choices can be complex, but understanding the potential risks and benefits can help us make informed decisions for our health and well-being.

Date :
  1. Date Completed 2008-09-25
  2. Date Revised 2022-04-04
Further Info :

Pubmed ID

18510583

DOI: Digital Object Identifier

10.1111/j.1532-5415.2008.01737.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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