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Differential effects of alpha 2-adrenoceptors in the modulation of the thermoregulatory response in mice induced by meperidine.
Author: BeinBerthold, HöckerJan, NielsenMartin, ParisAndrea, ScholzJens, TonnerPeter H
Original Abstract of the Article :
Meperidine proved to be more effective in treatment of shivering than equianalgesic doses of other opioids, especially pure mu-agonists. Further, meperidine has well known nonopioid actions including agonistic effects at alpha2-adrenoceptors in vitro. Accordingly, the authors investigated nonopioid ...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/18580178
データ提供:米国国立医学図書館(NLM)
The Thermoregulatory Dance: Meperidine and Alpha 2-Adrenoceptors
My dear colleagues, let's embark on a journey to the fascinating world of thermoregulation. This study, like a camel navigating the shifting sands of the desert, explores the complex interplay between meperidine, a common painkiller, and alpha 2-adrenoceptors, key players in temperature regulation. The researchers used a mouse model to investigate the non-opioid effects of meperidine on thermoregulation, a process as intricate as the delicate balance of an ecosystem in the desert. Their findings, as detailed as a map of the desert, highlight the specific roles of different alpha 2-adrenoceptor subtypes in modulating the thermoregulatory response to meperidine. This study provides valuable insights into the potential mechanisms underlying meperidine's unique effects on temperature regulation.Decoding the Thermoregulatory Puzzle: Alpha 2-Adrenoceptors and Meperidine
This study, like a skilled desert navigator deciphering a map, reveals a crucial element of the thermoregulatory puzzle. The researchers discovered that different alpha 2-adrenoceptor subtypes play distinct roles in modulating the thermoregulatory response to meperidine. This finding, as important as finding a hidden water source in the desert, provides a new understanding of the complex interplay between these receptors and the drug's effects on temperature regulation. This study highlights the need for further research to explore the potential therapeutic applications of this knowledge.Navigating the Desert of Thermoregulation: Understanding the Role of Alpha 2-Adrenoceptors
This study, like a compass guiding us through the vast landscape of thermoregulation, provides valuable insights into the complex interactions between meperidine and alpha 2-adrenoceptors. The researchers' findings suggest that different alpha 2-adrenoceptor subtypes play distinct roles in modulating the thermoregulatory response to meperidine, a discovery as significant as finding a new path across the desert. This study underscores the importance of continued research to fully understand the intricacies of thermoregulation and its potential implications for drug development and treatment strategies.Dr.Camel's Conclusion
This study, like a sandstorm in the desert, reveals the complexity and dynamism of thermoregulation. It highlights the importance of understanding the specific roles of alpha 2-adrenoceptors in modulating the effects of meperidine. This research, like a hidden oasis in the desert, provides a valuable starting point for further exploration of the complex interplay between drugs and the body's intricate regulatory systems.Date :
- Date Completed 2008-07-21
- Date Revised 2013-11-21
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