Neural basis of Delta-9-tetrahydrocannabinol and cannabidiol: effects during response inhibition.

Author: AllenPaul, AtakanZerrin, BhattacharyyaSagnik, BorgwardtStefan J, CrippaJose A, FraccaroValter, Fusar-PoliPaolo, Martin-SantosRocio, McGuirePhilip K, O'CarrollColin, RubiaKatya, SealMarc L

Paper Details 
Original Abstract of the Article :
BACKGROUND: This study examined the effect of Delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on brain activation during a motor inhibition task. METHODS: Functional magnetic resonance imaging and behavioural measures were recorded while 15 healthy volunteers performed a Go/No-Go task foll...See full text at original site
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引用元:
https://doi.org/10.1016/j.biopsych.2008.05.011

データ提供:米国国立医学図書館(NLM)

The Brain on Weed: THC and CBD's Impact on Response Inhibition

This is a fascinating study in the field of [neuropharmacology] examining the effects of [THC] and [CBD] on brain activity during a [motor inhibition task]. The researchers used [functional magnetic resonance imaging (fMRI)] and [behavioral measures] to investigate the effects of these cannabinoids on a group of [15 healthy volunteers].

Their findings are quite interesting. [THC] was found to reduce brain activity in areas associated with [response inhibition], like the [right inferior frontal] and [anterior cingulate gyrus]. Conversely, [CBD] appeared to decrease activity in regions not typically associated with [response inhibition], namely the [left temporal cortex] and [insula]. It's important to note that these effects were not tied to changes in [anxiety], [intoxication], [sedation], or [psychotic symptoms].

THC's Impact on Our Ability to Stop

This research suggests that [THC] might affect our ability to control our impulses. Just like a camel in the desert, we rely on our [frontal cortex] to help us stay focused and make sound decisions. THC's influence on this area might be similar to a mirage, making it difficult to distinguish between what's real and what's not.

Think Before You Smoke: CBD's Complex Role

The fact that [CBD] affects brain areas not directly involved in [response inhibition] is intriguing. It reminds me of how a gentle breeze can shift the sands of the desert, causing unexpected ripples in the landscape. CBD's complex effects on the brain need further exploration, as they might hold potential benefits for various conditions.

Dr.Camel's Conclusion

This study provides valuable insight into the impact of [THC] and [CBD] on the brain, particularly regarding [response inhibition]. It's a reminder that these compounds have complex effects on our cognitive processes, and further research is crucial to fully understand their implications. The desert of knowledge surrounding cannabinoids is vast, and we've only just scratched the surface!

Date :
  1. Date Completed 2009-04-08
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

18589404

DOI: Digital Object Identifier

10.1016/j.biopsych.2008.05.011

Related Literature

SNS
PICO Info
in preparation
Languages

English

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