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[Management of antiviral-resistant chronic hepatitis B virus infection].

Author: YimHyung Joon

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

While nucleoside analogues are effective in treating chronic hepatitis B, antiviral resistance is a major concern. This review describes strategies for managing antiviral-resistant chronic HBV infection, considering recent guidelines. Resistance to lamivudine/telbivudine can be managed by adding adefovir or switching to adefovir or entecavir. For adefovir resistance, adding or switching to entecavir is recommended. To avoid resistance development, antiviral therapy should be initiated after careful risk-benefit assessment, selecting the most potent agent with the lowest resistance rate.
Paper Details　
Original Abstract of the Article :
Substantial progress has been made in the treatment of chronic hepatitis B during the past decade. Nucleos(t)ide analogues are now widely used due to their convenience, less side effects, and considerable response rates. However, development of antiviral resistance is a major problem being considere...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/18604136

データ提供：米国国立医学図書館（NLM）

Antiviral Resistance: A Shifting Sandscape in the Desert of Hepatitis B

Hepatitis B, a viral infection that can cause liver damage, is like a persistent sandstorm that can erode the health of those affected. This study addresses the challenge of antiviral resistance in chronic hepatitis B virus (HBV) infection, a critical issue that can undermine the effectiveness of treatment. The researchers, like expert desert navigators, carefully analyze the mechanisms of antiviral resistance and explore strategies for managing this complication, seeking to ensure the long-term effectiveness of treatments.

A Constant Battle: Antiviral Resistance in Hepatitis B Treatment

The study highlights the dynamic nature of antiviral resistance in HBV, emphasizing the need for careful monitoring and adjustments to treatment strategies. This finding is like navigating a shifting landscape in the desert, where the terrain can change unexpectedly, requiring adaptability and vigilance. The research explores a range of treatment options for managing antiviral resistance, providing valuable insights into the evolving landscape of HBV treatment.

Navigating the Desert of Viral Infections

This research underscores the importance of a multi-pronged approach to managing chronic HBV infection, combining careful patient monitoring, judicious use of antiviral agents, and ongoing research to develop new therapies. It emphasizes the need to stay ahead of the curve in the fight against viral resistance, like a skilled scout mapping the desert terrain, anticipating and overcoming obstacles to ensure effective treatment.

Dr. Camel's Conclusion

This study ventures into the complex and ever-shifting desert of hepatitis B treatment, uncovering the challenges posed by antiviral resistance. It highlights the need for vigilance, adaptability, and ongoing research to develop effective strategies for managing this complication. The study serves as a reminder that the fight against viral infections is a continuous journey, requiring ongoing innovation and determination to ensure the well-being of patients.
Date :
  1. Date Completed 2008-09-12
  2. Date Revised 2020-12-14
Further Info :

Pubmed ID

18604136

DOI: Digital Object Identifier

200806254

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Languages

Korean

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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