Paper Details

  1. Home
  2. Paper Details

Comparison of cardioprotective effects of salvianolic acid B and benazepril on large myocardial infarction in rats.

Author: HeHai-Bo, LiLian-Da, ShiMeng-Qiong, WuLi-Mao, YangXian-Zhe, ZengXiao-Wei

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Retracted PublicationCases where a publication has been formally withdrawn due to the discovery of serious errors or misconduct.

Overview

Salvianolic acid B and benazepril both improved echocardiographic, hemodynamic and hemorheological parameters in rats with myocardial infarction. Both drugs also reduced infarct size and attenuated heart hypertrophy, left ventricular dilatation, and fibrosis. However, Sal B uniquely promoted angiogenesis and augmented VEGF expression in the heart, which may improve myocardial microcirculation.
Paper Details　
Original Abstract of the Article :
In the present study, we compared cardioprotective effects of salvianolic acid B (Sal B) and the angiotension-converting enzyme inhibitor, benazepril, in rats with large myocardial infarction (MI). The large MI was produced by coronary artery ligation for 4 weeks in rats. The rats were divided into ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/18622062

データ提供：米国国立医学図書館（NLM）

Salvianolic Acid B: A Promising Oasis for Cardioprotection

[Myocardial infarction (MI)] is a serious heart condition that can lead to significant damage. This research investigates the cardioprotective effects of [salvianolic acid B (Sal B)], a compound derived from the Chinese herb [Salvia miltiorrhiza], and compares them to [benazepril], an angiotensin-converting enzyme inhibitor, in rats with large MI.

The researchers found that both Sal B and benazepril showed similar cardioprotective effects in rats with MI, including improved echocardiographic parameters, reduced infarct size, and attenuated heart hypertrophy. However, Sal B exhibited unique effects, promoting angiogenesis and augmenting [vascular endothelium growth factor (VEGF)] expression in the heart.

Exploring the Potential of Traditional Medicines

The study suggests that Sal B holds promise as a cardioprotective agent and highlights the potential of traditional medicines for treating cardiovascular disease.

Maintaining Cardiovascular Health

This research underscores the importance of maintaining cardiovascular health through lifestyle modifications, such as regular exercise, a balanced diet, and avoiding smoking. It's also essential to consult with your doctor about any concerns you have about your heart health.

Dr.Camel's Conclusion

This research is like a hidden oasis in the desert of cardiovascular research, revealing the potential of Sal B as a promising cardioprotective agent. It's a reminder that nature holds a wealth of potential remedies, and traditional medicines deserve further exploration in the pursuit of improved heart health.

Date :
  1. Date Completed 2009-01-15
  2. Date Revised 2020-01-06
Further Info :

Pubmed ID

18622062

DOI: Digital Object Identifier

18622062

Related Literature

Article Analysis
・Effects of benazepril
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.