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Characteristics of panic disorder patients responding to placebo.

Author: BeckP, MellergårdM, OttossonJ O, RosenbergN K, RosenbergR

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study investigated the response to placebo in 41 patients with panic disorder. While more patients in the placebo group dropped out of the study compared to those receiving active medications, a significant number of patients in the placebo group showed improvement, with 34% experiencing no panic attacks and 23% showing substantial improvement on a clinical rating scale. These responders had fewer panic attacks initially, lower levels of overall mental health issues, and sought help less often. The study suggests that these individuals may be more receptive to psychotherapy as they seem to have better coping mechanisms and less distress.
Paper Details　
Original Abstract of the Article :
Forty-one panic disorder patients receiving placebo were investigated in a double-blind comparison of alprazolam, imipramine and placebo in panic disorder. A significantly higher drop-out rate was found in the placebo group than in the active treatment groups, but placebo response was found in 34% o...See full text at original site
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引用元：
https://doi.org/10.1111/j.1600-0447.1991.tb03099.x

データ提供：米国国立医学図書館（NLM）

Characteristics of Panic Disorder Patients Responding to Placebo

Panic disorder, a debilitating anxiety disorder, poses significant challenges for individuals and their families. This study investigated the characteristics of panic disorder patients who responded to placebo treatment in a double-blind comparison of alprazolam, imipramine, and placebo.

The Power of Expectation: Navigating the Desert of Panic

The study found that 34% of patients in the placebo group experienced a reduction in panic attacks to zero, and 23% showed significant improvement as measured by the Physician Global Improvement Scale. The responders to placebo exhibited fewer panic attacks at baseline, less psychopathology, and were less help-seeking than the nonresponders. This suggests that factors such as expectations and perceived control can influence treatment outcomes, even in the absence of active medication. This finding is analogous to the power of a mirage in the desert, where the illusion of water can provide temporary relief to a thirsty traveler.

Understanding Placebo Response: A Deeper Dive into the Desert

This study sheds light on the complexities of placebo response in panic disorder. The findings highlight the need for a comprehensive understanding of factors that contribute to treatment outcomes, including psychological and behavioral variables. By exploring the mechanisms underlying placebo response, researchers can gain valuable insights into the mind-body connection and develop more effective treatment strategies.

Dr.Camel's Conclusion

This study emphasizes the importance of considering the role of placebo response in panic disorder treatment. The findings suggest that factors such as expectations and perceived control can significantly influence treatment outcomes. This understanding can inform the development of more effective treatment strategies that incorporate both pharmacological and psychological interventions.
Date :
  1. Date Completed 1991-09-05
  2. Date Revised 2019-10-22
Further Info :

Pubmed ID

1862732

DOI: Digital Object Identifier

10.1111/j.1600-0447.1991.tb03099.x

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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