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Alprazolam, imipramine and placebo treatment of panic disorder: predicting therapeutic response.

Author: BechP, MellergårdM, OttossonJ O, RosenbergR

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study investigated factors influencing treatment outcomes for panic disorder in 123 patients receiving alprazolam, imipramine, or placebo. The study found that initial symptom severity was the strongest predictor of improvement, with more severe symptoms at the start of treatment associated with poorer outcomes. This effect was consistent across all treatments. The study also found a significant placebo response in a subgroup of patients. Other factors, such as avoidance behavior, gender, age, and past treatment experience, had limited impact on outcomes.
Paper Details　
Original Abstract of the Article :
Factors that predicted the outcome of drug treatment (alprazolam or imipramine) of panic disorder were studied in a sample of 123 Scandinavian patients participating in a multicenter placebo-controlled 8-week trial. The attrition rate was 95% for alprazolam, 73% for imipramine and 46% for placebo. F...See full text at original site
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引用元：
https://doi.org/10.1111/j.1600-0447.1991.tb03101.x

データ提供：米国国立医学図書館（NLM）

Unraveling the Mystery of Panic Disorder Treatment

Panic disorder, a condition marked by sudden intense fear and anxiety, can feel like a sandstorm swirling around you, leaving you feeling lost and overwhelmed. This study delved into the factors that might predict the effectiveness of different treatments for this debilitating disorder. The researchers conducted a multicenter, placebo-controlled trial involving 123 patients, meticulously comparing the effects of alprazolam, imipramine, and placebo.

Predicting Panic Disorder Treatment Response

The results suggest that the severity of symptoms at the start of treatment plays a significant role in determining the outcome. It's like navigating a desert with a compass - the more severe the initial symptoms, the greater the challenge in finding a clear path to recovery. This research provides valuable insights for clinicians who are trying to tailor treatments for individuals with panic disorder.

Living with Panic Disorder: A Desert Journey

Panic disorder can feel like traversing a vast and uncertain desert, with sudden and unpredictable storms that threaten your peace of mind. The findings from this study offer a glimmer of hope, suggesting that understanding the factors that predict treatment response can help individuals find more effective ways to manage their symptoms. It's important to remember that with persistence and the right support, you can navigate this challenging terrain and find a sense of calm.

Dr.Camel's Conclusion

This research sheds light on the complexity of panic disorder treatment. It's important to acknowledge that while there is no one-size-fits-all approach, understanding individual factors can help tailor treatment plans to improve patient outcomes. Like a camel adapting to the desert, individuals with panic disorder can learn to cope with their symptoms and find ways to thrive in a challenging environment.

Date :
  1. Date Completed 1991-09-05
  2. Date Revised 2019-10-22
Further Info :

Pubmed ID

1862734

DOI: Digital Object Identifier

10.1111/j.1600-0447.1991.tb03101.x

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PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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