Morphine versus mexiletine for treatment of postamputation pain: a randomized, placebo-controlled, crossover trial.

Author: AgarwalShefali, ClarkMichael R, HaythornthwaiteJennifer A, KlickBrendan, MaxMitchell B, RajaSrinivasa N, TellaPrabhav K, WuChristopher L

Paper Details 
Original Abstract of the Article :
BACKGROUND: Stump and phantom pains are debilitating sequelae of amputations that are often resistant to treatment. The efficacy of pharmacologic therapies, including opioids and sodium channel blockers, for postamputation pain is uncertain. METHODS: The authors conducted a double-blind, randomized...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/18648238

データ提供:米国国立医学図書館(NLM)

Navigating the Desert of Postamputation Pain: Comparing Morphine and Mexiletine

Postamputation pain, my friend, is a condition as debilitating as navigating a desolate and unforgiving desert. This study compares the effectiveness of two different medications, morphine and mexiletine, in managing this type of pain. It's like testing two different paths through the desert, seeking the most effective route to alleviate suffering.

Seeking Relief in the Desert of Pain

The authors, like skilled healers, conducted a double-blind, randomized, placebo-controlled, crossover study to assess the efficacy of morphine and mexiletine in managing postamputation pain. Their findings, like finding a hidden oasis in the desert, revealed that morphine was significantly more effective than both placebo and mexiletine in reducing pain intensity.

Finding a Path to Relief in the Desert

This research offers valuable insights into the management of postamputation pain, highlighting the potential of morphine as a more effective treatment option compared to mexiletine. It's like discovering a well-worn path through the desert, offering a clearer and more direct route to relief. However, the study also emphasizes the need to weigh the potential benefits of morphine against its associated side effects, reminding us that even in the desert of pain, we must carefully navigate to find the most effective and sustainable solution.

Dr. Camel's Conclusion

This research provides valuable insights into the management of postamputation pain, offering a comparison of two potential treatments. It's a reminder that even in the most challenging deserts of pain and suffering, we can find paths to relief and hope through careful observation, testing, and understanding of the different options available.

Date :
  1. Date Completed 2008-08-07
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

18648238

DOI: Digital Object Identifier

NIHMS82783

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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