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Morphine versus mexiletine for treatment of postamputation pain: a randomized, placebo-controlled, crossover trial.
Author: AgarwalShefali, ClarkMichael R, HaythornthwaiteJennifer A, KlickBrendan, MaxMitchell B, RajaSrinivasa N, TellaPrabhav K, WuChristopher L
Original Abstract of the Article :
BACKGROUND: Stump and phantom pains are debilitating sequelae of amputations that are often resistant to treatment. The efficacy of pharmacologic therapies, including opioids and sodium channel blockers, for postamputation pain is uncertain. METHODS: The authors conducted a double-blind, randomized...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://pubmed.ncbi.nlm.nih.gov/18648238
データ提供:米国国立医学図書館(NLM)
Navigating the Desert of Postamputation Pain: Comparing Morphine and Mexiletine
Postamputation pain, my friend, is a condition as debilitating as navigating a desolate and unforgiving desert. This study compares the effectiveness of two different medications, morphine and mexiletine, in managing this type of pain. It's like testing two different paths through the desert, seeking the most effective route to alleviate suffering.
Seeking Relief in the Desert of Pain
The authors, like skilled healers, conducted a double-blind, randomized, placebo-controlled, crossover study to assess the efficacy of morphine and mexiletine in managing postamputation pain. Their findings, like finding a hidden oasis in the desert, revealed that morphine was significantly more effective than both placebo and mexiletine in reducing pain intensity.
Finding a Path to Relief in the Desert
This research offers valuable insights into the management of postamputation pain, highlighting the potential of morphine as a more effective treatment option compared to mexiletine. It's like discovering a well-worn path through the desert, offering a clearer and more direct route to relief. However, the study also emphasizes the need to weigh the potential benefits of morphine against its associated side effects, reminding us that even in the desert of pain, we must carefully navigate to find the most effective and sustainable solution.
Dr. Camel's Conclusion
This research provides valuable insights into the management of postamputation pain, offering a comparison of two potential treatments. It's a reminder that even in the most challenging deserts of pain and suffering, we can find paths to relief and hope through careful observation, testing, and understanding of the different options available.
Date :
- Date Completed 2008-08-07
- Date Revised 2022-12-07
Further Info :
Related Literature
English
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