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Effects of age and gender on intravenous midazolam premedication: a randomized double-blind study.

Author: ChenP-Y, ChiaY-Y, HsuM-C, ShawF-Z, SunG-C

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Age and gender differences in neuropsychological and physiological responses after midazolam premedication were evident, suggesting dosage adjustments based on these covariates are necessary.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Given the potentially important effects that age and gender may have on midazolam premedication, this study aimed at determining if these factors alter anxiety, sedation, and cardiorespiratory outcomes when administering two different doses of i.v. midazolam. METHODS: After randomizatio...See full text at original site
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引用元：
https://doi.org/10.1093/bja/aen251

データ提供：米国国立医学図書館（NLM）

Navigating the Sands of Midazolam Premedication

The world of anesthesia is a complex desert, where navigating the delicate balance of sedation and anxiety reduction is paramount. This study delves into the nuanced effects of intravenous midazolam premedication, considering the age and gender of patients. Utilizing a [randomized double-blind study] design, researchers investigated the impact of two different doses of midazolam on anxiety levels, sedation, and cardiorespiratory outcomes. The study concluded that age and gender significantly influence these outcomes, highlighting the need for careful dose adjustments based on these factors.

Personalized Anesthesia: A Crucial Step in the Desert

The study's findings emphasize the critical importance of individualizing anesthesia care. This research suggests that a one-size-fits-all approach to midazolam premedication can lead to suboptimal outcomes, potentially impacting patient safety. The researchers observed that a dose of 0.02 mg/kg was effective in producing sedation and anxiolysis with minimal cardiorespiratory effects, but this dose may need to be adjusted based on the patient's age and gender.

The Importance of Tailoring Anesthesia

Just as a desert traveler must adapt to the changing terrain, healthcare professionals must consider individual factors when providing anesthesia. This research underscores the value of a personalized approach to anesthesia, ensuring that patients receive the right dose of medication at the right time, leading to a smoother and safer experience. This study serves as a reminder that even in the seemingly vast and homogenous desert of anesthesia, individual patients are unique and require customized care.

Dr. Camel's Conclusion

This study illuminates the intricate landscape of midazolam premedication, revealing that age and gender are crucial factors in determining the appropriate dose. By acknowledging these individual differences, we can better navigate the desert of anesthesia, ensuring patient safety and optimal outcomes.

Date :
  1. Date Completed 2008-11-18
  2. Date Revised 2022-03-21
Further Info :

Pubmed ID

18772216

DOI: Digital Object Identifier

10.1093/bja/aen251

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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