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Progress on BIG 1-02/IBCSG 27-02/NSABP B-37, a prospective randomized trial evaluating chemotherapy after local therapy for isolated locoregional recurrences of breast cancer.

Author: AebiStefan, AndersonStewart J, GelberShari, LángIstván, MamounasEleftherios P, RobidouxAndré, WapnirIrene L, WolmarkNorman

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Whether chemotherapy is beneficial for women whose early breast cancer has returned locally or regionally after initial treatment is uncertain. An international study is underway to determine the effectiveness of chemotherapy in these women, either alone or in combination with hormone therapy and trastuzumab.
Paper Details　
Original Abstract of the Article :
The utility of chemotherapy for women who experience a locoregional recurrence after primary treatment of early breast cancer remains an open question. An international collaborative trial is being conducted by the Breast International Group (BIG), the International Breast Cancer Study Group (IBCSG)...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/18784962

データ提供：米国国立医学図書館（NLM）

Chemotherapy for Locoregional Recurrences in Breast Cancer: A Complex Landscape

Breast cancer treatment is a vast and challenging landscape, often requiring a multidisciplinary approach to ensure optimal outcomes. This research explores the role of chemotherapy in managing locoregional recurrences after primary treatment for early breast cancer. The study, conducted by an international collaborative effort, seeks to determine the effectiveness of cytotoxic therapy in this specific context.

The researchers, like explorers mapping a new territory, are meticulously analyzing data from a large-scale, prospective randomized trial. Their goal is to provide definitive answers regarding the role of chemotherapy in this challenging scenario. The study explores the potential benefits of chemotherapy alone or in combination with other therapies, such as hormonal therapy and trastuzumab.

The research highlights the need for a comprehensive approach to managing locoregional recurrences in breast cancer. It underscores the importance of carefully evaluating the risks and benefits of different treatment options and tailoring treatment plans to individual patient needs.

Navigating the Path to Optimal Outcomes

This research aims to provide valuable guidance on the appropriate use of chemotherapy in managing locoregional recurrences in breast cancer. It underscores the importance of evidence-based decision-making and personalized treatment strategies.

Dr. Camel's Conclusion

This research reflects the ongoing commitment of researchers to finding the most effective and safe treatments for breast cancer. It's a reminder that the battle against this disease is a complex and dynamic one, much like navigating the shifting sands of a desert landscape. This study underscores the importance of collaboration and rigorous scientific investigation in advancing our understanding of this challenging disease.

Date :
  1. Date Completed 2009-01-29
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

18784962

DOI: Digital Object Identifier

NIHMS69759

Related Literature

Article Analysis
・Effective treatment of breast cancer
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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