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Adherence to treatment for latent tuberculosis infection: systematic review of studies in the US and Canada.

Author: ColsonP W, DaftaryA, FranksJ, Hirsch-MovermanY

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Treating latent tuberculosis infection (LTBI) is essential for reducing the spread of tuberculosis (TB). However, treatment adherence rates are consistently low in the United States and Canada. This systematic review of 78 studies found that adherence and completion rates for LTBI treatment are suboptimal across high-risk groups. While several interventions have been developed to improve adherence, no single intervention has shown consistent effectiveness. This highlights the need for innovative approaches to improve LTBI treatment adherence and ensure successful TB elimination.
Paper Details　
Original Abstract of the Article :
BACKGROUND: There is renewed attention to the critical role of successfully treating latent tuberculosis infection (LTBI) in reducing the overall impact of tuberculosis (TB). However, levels of treatment adherence are consistently low in industrialized countries such as the United States and Canada....See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/18926033

データ提供：米国国立医学図書館（NLM）

Navigating the Labyrinth of Latent Tuberculosis Infection Treatment

The fight against tuberculosis (TB) requires a multi-pronged approach, including effective treatment of latent tuberculosis infection (LTBI). This systematic review delves into the complexities of adherence to treatment for LTBI in the United States and Canada, highlighting the importance of successful treatment in reducing the overall impact of TB.

The authors conducted a thorough review of studies published between 1997 and 2007, examining adherence rates, predictors of adherence, and interventions designed to improve adherence. They discovered that adherence and completion rates of LTBI treatment remain suboptimal across high-risk groups, regardless of the chosen regimen. Despite efforts to understand the factors influencing adherence, consistent associations between patient factors, clinic facilities, or treatment characteristics have proven elusive.

Unraveling the Threads of Adherence

The study highlights the need for innovative approaches to addressing the challenges of LTBI treatment adherence. While a range of interventions have been developed to improve adherence, none have demonstrated consistent effectiveness. The authors emphasize the need for a tailored approach to LTBI treatment, acknowledging that a 'one-size-fits-all' approach is unlikely to succeed across all settings.

The Path to TB Elimination: A Collaborative Effort

This study underscores the importance of a collaborative effort between healthcare professionals, researchers, and policymakers in addressing the challenges of LTBI treatment. By identifying the barriers to adherence and treatment completion, researchers can develop effective, individualized interventions. Like a caravan navigating the vast desert, we must work together to overcome the obstacles and ensure that everyone has access to the treatment they need to effectively manage LTBI.

Dr.Camel's Conclusion

This research reminds us that the fight against TB is a journey through a complex and ever-changing landscape. Effective treatment of LTBI is crucial for achieving the goal of TB elimination, but the challenges of adherence require a multifaceted approach. By understanding the barriers to adherence and developing tailored interventions, we can pave the way for a healthier future, free from the scourge of TB.

Date :
  1. Date Completed 2009-02-04
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

18926033

DOI: Digital Object Identifier

18926033

SNS
PICO Info
in preparation
Languages

English

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