Phase III randomized study: oral pilocarpine versus submandibular salivary gland transfer protocol for the management of radiation-induced xerostomia.

Author: BarnabyPam, BlackMartin, ButlerJames, GhoshSunita, HarrisJeffrey, HierMichael, JhaNaresh, KerrPaul, SeikalyHadi, SultanemKhalil, SutherlandDonna, WilliamsDavid

Paper Details 
Original Abstract of the Article :
BACKGROUND: Xerostomia is a serious morbidity of radiation treatment in head and neck cancer. METHODS: We conducted a prospective phase III multicenter randomized study comparing submandibular salivary gland transfer (SGT) procedure with pilocarpine during and for 3 months after XRT. Salivary flow ...See full text at original site
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引用元:
https://doi.org/10.1002/hed.20961

データ提供:米国国立医学図書館(NLM)

Combatting Xerostomia: Finding Oasis in the Desert of Radiation-Induced Dry Mouth

Radiation therapy, a powerful weapon in the fight against cancer, can sometimes have unintended consequences. Xerostomia, or dry mouth, is a common side effect, leaving patients feeling like they are traversing a desert. This study, like a compassionate explorer seeking solutions, compares two treatment approaches for radiation-induced xerostomia: submandibular salivary gland transfer (SGT) and oral pilocarpine. The results, like a wellspring in the desert, show that SGT outperformed pilocarpine in improving salivary flow and overall quality of life.

Salivary Gland Transfer: A Potential Oasis for Xerostomia

This research, like a ray of hope in the desert, unveils the potential of SGT for combating xerostomia. The findings suggest that SGT, a more invasive procedure, can significantly improve salivary flow and overall quality of life compared to pilocarpine, a less invasive option. This information is crucial for patients and healthcare providers to weigh the potential benefits and risks of each treatment approach.

Navigating Dry Mouth: Seeking Relief in the Desert

This research, like a map guiding a traveler through a dry and barren landscape, provides valuable information for patients experiencing xerostomia. It highlights the potential of SGT as a treatment option, while also acknowledging the need for further research to fully understand its long-term effectiveness and to explore other potential interventions.

Dr. Camel's Conclusion

This study, like a camel caravan discovering a new oasis, unveils the potential of salivary gland transfer as a treatment for radiation-induced xerostomia. It highlights the importance of exploring different treatment options and making informed decisions about the best approach for individual patients.

Date :
  1. Date Completed 2009-05-21
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

19107948

DOI: Digital Object Identifier

10.1002/hed.20961

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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