Efficacy and safety of adding the dipeptidyl peptidase-4 inhibitor alogliptin to metformin therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy: a multicentre, randomised, double-blind, placebo-controlled study.

Author: , EllisG C, FleckP R, MekkiQ, NauckM A, WilsonC A

Paper Details 
Original Abstract of the Article :
AIMS: To evaluate the efficacy and safety of alogliptin, a new dipeptidyl peptidase-4 inhibitor, for 26 weeks at once-daily doses of 12.5 and 25 mg in combination with metformin in patients whose HbA(1c) levels were inadequately controlled on metformin alone. METHODS AND PATIENTS: Patients with typ...See full text at original site
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引用元:
https://doi.org/10.1111/j.1742-1241.2008.01933.x

データ提供:米国国立医学図書館(NLM)

Aligning Glycemic Control: Alogliptin's Role in Type 2 Diabetes Management

Type 2 diabetes is a complex and chronic condition affecting millions of people worldwide, requiring ongoing management to maintain optimal blood sugar levels. This study investigates the potential of alogliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, as an adjunct to metformin therapy in patients with type 2 diabetes inadequately controlled on metformin alone. Researchers aimed to assess the efficacy and safety of alogliptin in improving glycemic control and reducing the risk of complications associated with type 2 diabetes. Their findings revealed that alogliptin, at both 12.5 mg and 25 mg doses, significantly improved HbA1c levels and fasting plasma glucose concentrations compared to placebo. Moreover, alogliptin was generally well-tolerated, with minimal side effects. These results suggest that alogliptin could be a valuable tool in managing type 2 diabetes, offering a potential solution for patients struggling to achieve optimal glycemic control.

Improving Glycemic Control: Alogliptin's Potential in Type 2 Diabetes Management

This study highlights the potential of alogliptin in improving glycemic control for patients with type 2 diabetes, offering a promising new approach to managing this challenging condition. The significant improvements in HbA1c levels and fasting plasma glucose concentrations, coupled with a favorable safety profile, suggest that alogliptin could be a valuable addition to the therapeutic armamentarium for managing type 2 diabetes.

A New Path to Better Health: Navigating the Desert of Type 2 Diabetes

This study underscores the importance of ongoing research and innovation in the field of diabetes management. By developing new drugs like alogliptin, we can improve the lives of patients with type 2 diabetes, empowering them to manage their condition effectively and achieve better overall health.

Dr. Camel's Conclusion

This study is a testament to the ongoing quest for better treatment options for type 2 diabetes, much like a camel seeking a lush oasis in a vast and unforgiving desert. Alogliptin offers a promising new path towards improved glycemic control and better overall health for those living with this challenging condition.

Date :
  1. Date Completed 2009-05-15
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

19125992

DOI: Digital Object Identifier

10.1111/j.1742-1241.2008.01933.x

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SNS
PICO Info
in preparation
Languages

English

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