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Effects of dose and dosing schedule of inhaled budesonide on bone turnover.

Author: BaskervilleJ, FraherL J, HodsmanA B, JenningsB, ToogoodJ H

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Budesonide, an inhaled steroid, reduced serum osteocalcin levels, suggesting an inhibitory effect on bone formation. The clinical significance of this effect requires further investigation.
Paper Details　
Original Abstract of the Article :
To assess whether the use of larger than usual doses of inhaled steroid to treat severe asthma may adversely affect bone turnover and whether such an effect may be mitigated by altering the dose schedule, we investigated the effects of budesonide (BUD) on serum osteocalcin and the urinary output of ...See full text at original site
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引用元：
https://doi.org/10.1016/0091-6749(91)90150-m

データ提供：米国国立医学図書館（NLM）

Inhaled Budesonide and Bone Turnover: A Closer Look

The use of [inhaled corticosteroids] is a common treatment for [severe asthma]. While effective in managing asthma symptoms, concerns have been raised about potential adverse effects on [bone turnover]. This study investigates the impact of [budesonide (BUD)] on [serum osteocalcin] and [urinary output of hydroxyproline and calcium] in healthy adults. The researchers administered two doses of BUD (1.2 mg or 2.4 mg per day) and a placebo in a crossover, double-blind study, comparing morning versus diurnal dosing schedules.

Budesonide's Impact on Bone Turnover

The study found that both doses of BUD reduced [serum osteocalcin], a marker of bone formation. However, neither dose increased [urinary calcium or hydroxyproline], markers of bone resorption. The study also found that morning dosing resulted in higher levels of [osteocalcin and plasma cortisol] compared to diurnal dosing. This research highlights the importance of considering the potential impact of inhaled corticosteroids on bone health, particularly in patients at risk for osteoporosis.

Balancing Asthma Treatment with Bone Health

This study reminds us of the delicate balance between managing asthma and maintaining bone health. It's like navigating a desert with a limited water supply - we need to carefully manage our resources to ensure survival. This research provides valuable insights into the potential risks and benefits of inhaled corticosteroids, encouraging clinicians to carefully consider the individual needs of patients and weigh the potential risks and benefits of treatment.

Dr.Camel's Conclusion

This study underscores the importance of a holistic approach to healthcare, considering the potential effects of medications on different aspects of health. It's like a wise camel, always mindful of its surroundings and the needs of its journey, carefully navigating the challenges of the desert. By understanding the potential risks and benefits of medications and tailoring treatment plans to individual needs, we can create a healthier and more balanced journey for our patients.

Date :
  1. Date Completed 1991-11-18
  2. Date Revised 2019-07-23
Further Info :

Pubmed ID

1918724

DOI: Digital Object Identifier

10.1016/0091-6749(91)90150-m

Related Literature

Article Analysis
・Effects of budesonide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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