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A double-blind, randomized, placebo-controlled trial of paroxetine controlled-release in irritable bowel syndrome.

Author: KrulewiczStan, MannelliPaolo, MasandPrakash S, PaeChi-Un, PatkarAshwin A, PeindlKathleen, VariaIndu M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

The study did not demonstrate a statistically significant benefit for paroxetine-CR over placebo on the primary outcome measure, although there was improvement in secondary outcome measures. Overall, paroxetine-CR seems to have potential benefit in IBS.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Irritable bowel syndrome (IBS) is a functional gastrointestinal (GI) disease that causes significant impairment in quality of life and accounts for $8 billion per year to the healthcare system and loss of productivity in the workplace. OBJECTIVE: The authors examined the efficacy and sa...See full text at original site
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引用元：
https://doi.org/10.1176/appi.psy.50.1.78

データ提供：米国国立医学図書館（NLM）

Irritable Bowel Syndrome (IBS): A Desert of Digestive Distress

The study explores the challenging world of irritable bowel syndrome (IBS), a common and often debilitating condition affecting the digestive system. Like a camel navigating the treacherous dunes of a desert, the researchers explore the effectiveness of paroxetine controlled-release (paroxetine-CR) for managing IBS, seeking to alleviate the symptoms and improve quality of life for those affected. This research meticulously examines the evidence for the efficacy of paroxetine-CR for IBS, offering valuable insights for navigating this difficult terrain.

Paroxetine-CR: A Potential Oasis for IBS

The findings suggest that paroxetine-CR may have potential benefits for managing IBS, although further research is needed to confirm its effectiveness. This research offers valuable insights for individuals navigating the challenges of IBS, providing information on a potential treatment option. While further investigation is necessary to fully evaluate its efficacy, the findings suggest that paroxetine-CR could serve as a potential oasis in the desert of digestive distress for those suffering from IBS.

Navigating the Desert of IBS: A Guide for Patients

The study underscores the importance of seeking professional guidance for managing IBS, emphasizing the need for a tailored approach based on individual needs and circumstances. Like a desert guide, this research provides valuable insights for patients navigating the challenges of IBS, offering a roadmap for seeking effective treatment and managing the symptoms of this chronic condition.

Dr.Camel's Conclusion

This study explores the potential of paroxetine-CR as a treatment option for IBS, suggesting that it may offer benefits for managing symptoms and improving quality of life. While further research is needed to confirm its efficacy, the findings provide valuable insights for individuals navigating the challenges of IBS. It emphasizes the importance of seeking professional guidance and exploring treatment options that are tailored to individual needs and circumstances.
Date :
  1. Date Completed 2009-05-05
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

19213976

DOI: Digital Object Identifier

10.1176/appi.psy.50.1.78

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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