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Evaluation of buprenorphine in a postoperative pain model in rats.

Author: CurtinLeslie I, DiPirroJean M, GrakowskyJulie A, KristalMark B, MartinLisa B E, SuarezMauricio, ThompsonAlexis C

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study tested different doses of buprenorphine, an analgesic, on rats after surgery. It found that a dose of 0.05 mg/kg SC was effective at relieving pain without causing long-term changes in opioid sensitivity.
Paper Details　
Original Abstract of the Article :
We evaluated the commonly prescribed analgesic buprenorphine in a postoperative pain model in rats, assessing acute postoperative pain relief, rebound hyperalgesia, and the long-term effects of postoperative opioid treatment on subsequent opioid exposure. Rats received surgery (paw incision under is...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703135/

データ提供：米国国立医学図書館（NLM）

Buprenorphine for Postoperative Pain: A Camel's Journey Through the Sands of Analgesia

Ah, the pain of recovery! This study investigates the effectiveness of buprenorphine, a commonly prescribed analgesic, in a postoperative pain model in rats. The researchers wanted to determine the optimal dose for pain relief, assess the potential for rebound hyperalgesia, and investigate the long-term effects of postoperative opioid treatment on subsequent opioid exposure.

Finding the Right Dose: A Camel's Perspective

The study found that buprenorphine at a dose of 0.05 mg/kg SC was the most effective in providing pain relief during the acute postoperative period. This dose also did not induce long-term changes in opioid sensitivity. It's like finding the perfect oasis in the desert - the right dose can provide much-needed relief without lingering side effects.

Postoperative Pain Management: A Camel's Guide

This study highlights the importance of selecting the appropriate dose of buprenorphine for postoperative pain management. It also reminds us that long-term opioid use can lead to adaptations in the opioid system, potentially impacting future responses to pain medication. This study emphasizes the importance of careful monitoring and individualized care in managing postoperative pain.

Dr.Camel's Conclusion

This study provides valuable information for healthcare professionals and patients alike. It underscores the importance of selecting the appropriate dose of buprenorphine for postoperative pain management, considering both short-term and long-term effects. Remember, pain management is a complex journey, and finding the right path requires a thorough understanding of individual needs and potential medication interactions.

Date :
  1. Date Completed 2009-04-14
  2. Date Revised 2022-04-10
Further Info :

Pubmed ID

19295055

DOI: Digital Object Identifier

PMC2703135

Related Literature

Article Analysis
・Effects of buprenorphine injection (pain relief)
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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