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Novel synthesis and in vitro drug release of polymeric prodrug: Chitosan-O-isopropyl-5'-O-d4T monophosphate conjugate.
Author: HuLiming, LiChao, LiGang, LiZelin, QiaoRenzhong, YangLin, ZengRong
Original Abstract of the Article :
A novel approach to synthesize chitosan-O-isopropyl-5'-O-d4T monophosphate conjugate was developed. Chitosan-d4T monophosphate prodrug with a phosphoramidate linkage was efficiently synthesized through Atherton-Todd reaction. In vitro drug release studies in pH 1.1 and 7.4 indicated that chitosan-O-...See full text at original site
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引用元:
https://doi.org/10.1016/j.bmcl.2009.03.044
データ提供:米国国立医学図書館(NLM)
Chitosan-d4T Monophosphate: A Sustained Delivery System in the Desert of Antiretroviral Treatment
The field of drug delivery is constantly evolving, seeking more efficient and effective ways to deliver medications to the body. This research explores the use of chitosan, a natural polymer, as a carrier for the antiretroviral drug d4T. The authors developed a novel approach to synthesize a chitosan-d4T monophosphate conjugate, creating a sustained-release formulation for improved therapeutic efficacy. This innovative approach, akin to discovering a new and efficient way to transport resources across a vast desert, has the potential to revolutionize antiretroviral treatment.
Chitosan-d4T Monophosphate: A Promising Oasis in the Desert of HIV Treatment
The study found that chitosan-d4T monophosphate conjugate effectively released d4T over a prolonged period, suggesting a potential advantage over traditional formulations. This discovery, like finding a hidden oasis offering a sustainable source of water, could provide a more effective and convenient treatment option for individuals living with HIV. The researchers emphasize the need for further investigation to fully understand the pharmacokinetic and therapeutic implications of this novel delivery system.
Seeking New Pathways in the Desert of Antiretroviral Therapy
This research, like a well-charted trail through the desert of antiretroviral therapy, offers a promising new approach to drug delivery. The findings underscore the potential of chitosan as a carrier for antiretroviral drugs, offering hope for improved treatment outcomes and reduced side effects. The research encourages further investigation into the potential applications of this innovative delivery system.
Dr.Camel's Conclusion
This study, like a shimmering oasis in the desert of HIV treatment, showcases the potential of chitosan-d4T monophosphate conjugate as a sustained-release formulation for antiretroviral therapy. The findings offer a promising avenue for improving treatment efficacy and reducing side effects, ultimately enhancing the lives of those living with HIV.
Date :
- Date Completed 2009-08-21
- Date Revised 2013-11-21
Further Info :
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